DegronMD - Q96MT3(PRICKLE1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S562Y	TCGA-AZ-4315	COAD	TCGA	PRPSLYSLQ	DEG_APCC_DBOX_1	556:564	Mutation altering degron motif	0.6009
p.S562Y	DO8842	COAD	ICGC	PRPSLYSLQ	DEG_APCC_DBOX_1	556:564	Mutation altering degron motif	0.6009
p.P558S	TCGA-BR-8680	STAD	TCGA	PRPSLYSLQ	DEG_APCC_DBOX_1	556:564	Mutation altering degron motif	0.5641
p.P558S	DO47769	STAD	ICGC	PRPSLYSLQ	DEG_APCC_DBOX_1	556:564	Mutation altering degron motif	0.5641
p.E568K	TCGA-EE-A29C	SKCM	TCGA	PRPSLYSLQ	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.2222
p.E568K	DO222727	MELA	ICGC	PRPSLYSLQ	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.2222
p.E568K	DO38028	SKCM	ICGC	PRPSLYSLQ	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.2222
p.Q564K	TCGA-EO-A3AV	UCEC	TCGA	PRPSLYSLQ	DEG_APCC_DBOX_1	556:564	Mutation altering degron motif	0.5833
p.Q564K	DO52412	UCEC	ICGC	PRPSLYSLQ	DEG_APCC_DBOX_1	556:564	Mutation altering degron motif	0.5833
p.R750Q	TCGA-R6-A8W8	ESCA	TCGA	LGLYGE	LIG_APCC_ABBA_1	752:757	Mutation rewiring degron network	0.2778
p.R750W	TCGA-WE-A8ZT	SKCM	TCGA	LGLYGE	LIG_APCC_ABBA_1	752:757	Mutation rewiring degron network	0.2778
p.R750W	DO51290	SKCM	ICGC	LGLYGE	LIG_APCC_ABBA_1	752:757	Mutation rewiring degron network	0.2778
p.G753E	TCGA-Z2-AA3V	SKCM	TCGA	LGLYGE	LIG_APCC_ABBA_1	752:757	Mutation altering degron motif	0.6087
p.G753E	DO51303	SKCM	ICGC	LGLYGE	LIG_APCC_ABBA_1	752:757	Mutation altering degron motif	0.6087
p.P746S	DO229005	COCA	ICGC	LGLYGE	LIG_APCC_ABBA_1	752:757	Mutation rewiring degron network	0.1667
p.P746S	DO229354	LAML	ICGC	LGLYGE	LIG_APCC_ABBA_1	752:757	Mutation rewiring degron network	0.1667
p.P746S	DO52365	LUSC	ICGC	LGLYGE	LIG_APCC_ABBA_1	752:757	Mutation rewiring degron network	0.1667
p.E553Q	DO234239	ESAD	ICGC	PRPSLYSLQ	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.25
p.P558L	DO234403	ESAD	ICGC	PRPSLYSLQ	DEG_APCC_DBOX_1	556:564	Mutation altering degron motif	0.6471
p.N745K	DO44792	LICA	ICGC	LGLYGE	LIG_APCC_ABBA_1	752:757	Mutation rewiring degron network	0.1389
p.P746Q	SIDM00401	Melanoma	GDSC	LGLYGE	LIG_APCC_ABBA_1	752:757	Mutation rewiring degron network	0.1667
p.P746Q	ACH-000614	Skin Cancer	CCLE	LGLYGE	LIG_APCC_ABBA_1	752:757	Mutation rewiring degron network	0.1667
p.P746Q	ACH-002461	Skin Cancer	CCLE	LGLYGE	LIG_APCC_ABBA_1	752:757	Mutation rewiring degron network	0.1667
p.P746Q	RVH-421	skin	COSMIC	LGLYGE	LIG_APCC_ABBA_1	752:757	Mutation rewiring degron network	0.1667
p.Y561H	SIDM00929	Chondrosarcoma	GDSC	PRPSLYSLQ	DEG_APCC_DBOX_1	556:564	Mutation altering degron motif	0.6118
p.Y561H	ACH-000516	Bone Cancer	CCLE	PRPSLYSLQ	DEG_APCC_DBOX_1	556:564	Mutation altering degron motif	0.6118
p.Y561H	CAL-78	bone	COSMIC	PRPSLYSLQ	DEG_APCC_DBOX_1	556:564	Mutation altering degron motif	0.6118
p.D759N	SIDM00560	Gastric Carcinoma	GDSC	LGLYGE	LIG_APCC_ABBA_1	752:757	Mutation rewiring degron network	0.2778
p.D759N	ACH-000678	Gastric Cancer	CCLE	LGLYGE	LIG_APCC_ABBA_1	752:757	Mutation rewiring degron network	0.2778
p.D759N	MKN7	stomach	COSMIC	LGLYGE	LIG_APCC_ABBA_1	752:757	Mutation rewiring degron network	0.2778
p.T571A	SIDM00217	Colorectal Carcinoma	GDSC	PRPSLYSLQ	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.1389
p.T571A	SNU-1040	large intestine	COSMIC	PRPSLYSLQ	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.1389

Kaplan plot for PRICKLE1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRICKLE1

UniProt ID: Q96MT3

Entrez ID: 144165

Protein name: Prickle-like protein 1 (REST/NRSF-interacting LIM domain protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRICKLE1 in