DegronMD

Uniprot ID: Q96MT3

Source protein: Prickle-like protein 1

Source gene: PRICKLE1

Class: DEG_APCC_DBOX_1

Location: 556:564

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7164

ASA_SCORE: 83.8778

COIL: 0.7436

CONS_SCORE: 0.3463

DSS_SCORE: 0.5504

HELIX: 0.1847

FCONS_SCORE: 1.0039

RIG_SCORE: 0.7155

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S562Y	TCGA-AZ-4315	COAD	TCGA	PRPSLYSLQ	DEG_APCC_DBOX_1	0.6009
p.S562Y	DO8842	COAD	ICGC	PRPSLYSLQ	DEG_APCC_DBOX_1	0.6009
p.P558S	TCGA-BR-8680	STAD	TCGA	PRPSLYSLQ	DEG_APCC_DBOX_1	0.5641
p.P558S	DO47769	STAD	ICGC	PRPSLYSLQ	DEG_APCC_DBOX_1	0.5641
p.E568K	TCGA-EE-A29C	SKCM	TCGA	PRPSLYSLQ	DEG_APCC_DBOX_1	0.2222
p.E568K	DO222727	MELA	ICGC	PRPSLYSLQ	DEG_APCC_DBOX_1	0.2222
p.E568K	DO38028	SKCM	ICGC	PRPSLYSLQ	DEG_APCC_DBOX_1	0.2222
p.Q564K	TCGA-EO-A3AV	UCEC	TCGA	PRPSLYSLQ	DEG_APCC_DBOX_1	0.5833
p.Q564K	DO52412	UCEC	ICGC	PRPSLYSLQ	DEG_APCC_DBOX_1	0.5833
p.E553Q	DO234239	ESAD	ICGC	PRPSLYSLQ	DEG_APCC_DBOX_1	0.25
p.P558L	DO234403	ESAD	ICGC	PRPSLYSLQ	DEG_APCC_DBOX_1	0.6471
p.Y561H	SIDM00929	Chondrosarcoma	GDSC	PRPSLYSLQ	DEG_APCC_DBOX_1	0.6118
p.Y561H	ACH-000516	Bone Cancer	CCLE	PRPSLYSLQ	DEG_APCC_DBOX_1	0.6118
p.Y561H	CAL-78	bone	COSMIC	PRPSLYSLQ	DEG_APCC_DBOX_1	0.6118
p.T571A	SIDM00217	Colorectal Carcinoma	GDSC	PRPSLYSLQ	DEG_APCC_DBOX_1	0.1389
p.T571A	SNU-1040	large_intestine	COSMIC	PRPSLYSLQ	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96MT3	Prickle-like protein 1	DEG_APCC_DBOX_1	556:564	PRPSLYSLQ	APC,CDC20,FZR1	0.7164	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons