DegronMD

Uniprot ID: Q9HBR0

Source protein: Putative sodium-coupled neutral amino acid transporter 10

Source gene: SLC38A10

Class: LIG_APCC_ABBA_1

Location: 1056:1061

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6247

ASA_SCORE: 82.3833

COIL: 0.8422

CONS_SCORE: 0.2451

DSS_SCORE: 0.6334

HELIX: 0.1142

FCONS_SCORE: 0.7951

RIG_SCORE: 0.6168

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1054W	TCGA-97-7554	LUAD	TCGA	LGPHAE	LIG_APCC_ABBA_1	0.2778
p.R1054W	DO23592	LUAD	ICGC	LGPHAE	LIG_APCC_ABBA_1	0.2778
p.R1050W	TCGA-AA-A01P	COAD	TCGA	LGPHAE	LIG_APCC_ABBA_1	0.1667
p.R1050W	DO8642	COAD	ICGC	LGPHAE	LIG_APCC_ABBA_1	0.1667
p.R1050L	TCGA-D3-A3C7	SKCM	TCGA	LGPHAE	LIG_APCC_ABBA_1	0.1667
p.R1050L	DO47569	SKCM	ICGC	LGPHAE	LIG_APCC_ABBA_1	0.1667
p.H1059Q	DO232846	NACA	ICGC	LGPHAE	LIG_APCC_ABBA_1	0.7582
p.G1062R	DO233293	NACA	ICGC	LGPHAE	LIG_APCC_ABBA_1	0.3056
p.Q1063L	DO233296	NACA	ICGC	LGPHAE	LIG_APCC_ABBA_1	0.2778
p.R1054Q	SIDM00059	Ovarian Carcinoma	GDSC	LGPHAE	LIG_APCC_ABBA_1	0.2778
p.P1066S	SIDM01059	Melanoma	GDSC	LGPHAE	LIG_APCC_ABBA_1	0.1944
p.P1066S	ACH-000915	Skin Cancer	CCLE	LGPHAE	LIG_APCC_ABBA_1	0.1944
p.G1069R	ACH-001750	Sarcoma	CCLE	LGPHAE	LIG_APCC_ABBA_1	0.1111
p.R1053W	ACH-002511	Skin Cancer	CCLE	LGPHAE	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HBR0	Putative sodium-coupled neutral amino acid transporter 10	LIG_APCC_ABBA_1	1056:1061	LGPHAE	APC,CDC20,FZR1	0.6247	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons