DegronMD

Uniprot ID: A1L4H1

Source protein: Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D

Source gene: SSC5D

Class: DEG_SCF_FBW7_1

Location: 1459:1466

E3 ligase: FBXW7

DEGRON score: 0.9475

ASA_SCORE: 76.7625

COIL: 0.9604

CONS_SCORE: 0.4409

DSS_SCORE: 0.701

HELIX: 0.0093

FCONS_SCORE: 0.9682

RIG_SCORE: 0.5069

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1460E	DO10172	COAD	ICGC	LGPTPGQS	DEG_SCF_FBW7_1	0.6087
p.P1456S	DO230334	COCA	ICGC	LGPTPGQS	DEG_SCF_FBW7_1	0.25
p.P1456S	DO229016	COCA	ICGC	LGPTPGQS	DEG_SCF_FBW7_1	0.25
p.P1456S	DO229003	COCA	ICGC	LGPTPGQS	DEG_SCF_FBW7_1	0.25
p.P1456S	DO52365	LUSC	ICGC	LGPTPGQS	DEG_SCF_FBW7_1	0.25
p.P1456S	DO231018	LUSC	ICGC	LGPTPGQS	DEG_SCF_FBW7_1	0.25
p.P1456L	DO232064	ORCA	ICGC	LGPTPGQS	DEG_SCF_FBW7_1	0.25
p.C1473Y	SIDM02021	Esophageal Carcinoma	GDSC	LGPTPGQS	DEG_SCF_FBW7_1	0.1389
p.G1468C	SIDM00680	Colorectal Carcinoma	GDSC	LGPTPGQS	DEG_SCF_FBW7_1	0.2778
p.G1468C	ACH-000957	Colon/Colorectal Cancer	CCLE	LGPTPGQS	DEG_SCF_FBW7_1	0.2778
p.G1468C	LS-180	large_intestine	COSMIC	LGPTPGQS	DEG_SCF_FBW7_1	0.2778
p.D1450N	SIDM00630	Breast Carcinoma	GDSC	LGPTPGQS	DEG_SCF_FBW7_1	0.0833
p.D1450N	ACH-000876	Breast Cancer	CCLE	LGPTPGQS	DEG_SCF_FBW7_1	0.0833
p.D1450N	MDA-MB-415	breast	COSMIC	LGPTPGQS	DEG_SCF_FBW7_1	0.0833
p.P1453T	SIDM00767	Small Cell Lung Carcinoma	GDSC	LGPTPGQS	DEG_SCF_FBW7_1	0.1667
p.P1453T	ACH-001136	Lung Cancer	CCLE	LGPTPGQS	DEG_SCF_FBW7_1	0.1667
p.P1453T	NCI-H187	lung	COSMIC	LGPTPGQS	DEG_SCF_FBW7_1	0.1667
p.S1466N	SIDM00534	Colorectal Carcinoma	GDSC	LGPTPGQS	DEG_SCF_FBW7_1	0.7069
p.S1466N	ACH-000986	Colon/Colorectal Cancer	CCLE	LGPTPGQS	DEG_SCF_FBW7_1	0.7069
p.S1466N	HT-115	large_intestine	COSMIC	LGPTPGQS	DEG_SCF_FBW7_1	0.7069
p.P1461S	SIDM00220	Ovarian Carcinoma	GDSC	LGPTPGQS	DEG_SCF_FBW7_1	0.5641
p.P1461S	ACH-000962	Ovarian Cancer	CCLE	LGPTPGQS	DEG_SCF_FBW7_1	0.5641
p.P1461S	ACH-001145	Ovarian Cancer	CCLE	LGPTPGQS	DEG_SCF_FBW7_1	0.5641
p.P1461S	OC-314	ovary	COSMIC	LGPTPGQS	DEG_SCF_FBW7_1	0.5641
p.C1473R	SIDM00839	Colorectal Carcinoma	GDSC	LGPTPGQS	DEG_SCF_FBW7_1	0.1389
p.C1473R	ACH-000950	Colon/Colorectal Cancer	CCLE	LGPTPGQS	DEG_SCF_FBW7_1	0.1389
p.C1473R	LoVo	large_intestine	COSMIC	LGPTPGQS	DEG_SCF_FBW7_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LGPTPGQS

Degron related mutations and impact score

Drug responses associated with SSC5D mutations

All proteins holding degron of LGPTPGQS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1L4H1	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D	DEG_SCF_FBW7_1	1459:1466	LGPTPGQS	FBXW7	0.9475	More...