DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
LGPTPSQS
Uniprot ID:
P55011
Source protein:
Solute carrier family 12 member 2
Source gene:
SLC12A2
Class:
DEG_SCF_FBW7_1
Location:
72:79
E3 ligase:
FBXW7
DEGRON score:
0.999
ASA_SCORE:
73.8125
COIL:
0.8111
CONS_SCORE:
0.2758
DSS_SCORE:
0.6252
HELIX:
0.0956
FCONS_SCORE:
1.1859
RIG_SCORE:
0.6433
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with SLC12A2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LGPTPSQS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P55011
Solute carrier family 12 member 2
DEG_SCF_FBW7_1
72:79
LGPTPSQS
FBXW7
0.999
More...