DegronMD

Uniprot ID: Q8NFH5

Source protein: Nucleoporin NUP35

Source gene: NUP35

Class: DEG_SCF_FBW7_1

Location: 103:110

E3 ligase: FBXW7

DEGRON score: 0.9988

ASA_SCORE: 68.6625

COIL: 0.8644

CONS_SCORE: 0.5147

DSS_SCORE: 0.6352

HELIX: 0.0808

FCONS_SCORE: 1.0129

RIG_SCORE: 0.6466

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P101L	TCGA-12-0829	GBM	TCGA	LGSTPLTS	DEG_SCF_FBW7_1	0.2778
p.I94V	TCGA-EE-A29D	SKCM	TCGA	LGSTPLTS	DEG_SCF_FBW7_1	0.0833
p.F120Y	DO48290	ESCA	ICGC	LGSTPLTS	DEG_SCF_FBW7_1	0.0556
p.G116V	DO229027	LICA	ICGC	LGSTPLTS	DEG_SCF_FBW7_1	0.1667
p.V109F	DO29046	OV	ICGC	LGSTPLTS	DEG_SCF_FBW7_1	0.7068
p.P113T	DO37951	SKCM	ICGC	LGSTPLTS	DEG_SCF_FBW7_1	0.25
p.P97T	DO229272	THCA	ICGC	LGSTPLTS	DEG_SCF_FBW7_1	0.1667
p.T110A	DO39016	THCA	ICGC	LGSTPLTS	DEG_SCF_FBW7_1	0.7139
p.S111P	DO42312	UCEC	ICGC	LGSTPLTS	DEG_SCF_FBW7_1	0.3056
p.Q117H	DO42312	UCEC	ICGC	LGSTPLTS	DEG_SCF_FBW7_1	0.1389
p.I116T	SIDM00878	Breast Carcinoma	GDSC	LGSTPLTS	DEG_SCF_FBW7_1	0.1667
p.I116T	ACH-000930	Breast Cancer	CCLE	LGSTPLTS	DEG_SCF_FBW7_1	0.1667
p.I116T	HCC1569	breast	COSMIC	LGSTPLTS	DEG_SCF_FBW7_1	0.1667
p.L108S	ACH-000982	Colon/Colorectal Cancer	CCLE	LGSTPLTS	DEG_SCF_FBW7_1	0.6556
p.I99T	HCC1569	breast	COSMIC	LGSTPLTS	DEG_SCF_FBW7_1	0.6667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NFH5	Nucleoporin NUP35	DEG_SCF_FBW7_1	103:110	LGSTPLTS	FBXW7	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons