DegronMD - Q8NFH5(NUP35)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P101L	TCGA-12-0829	GBM	TCGA	LGSTPLTS	DEG_SCF_FBW7_1	103:110	Mutation rewiring degron network	0.2778
p.L271P	TCGA-B5-A1MX	UCEC	TCGA	PGSTPRIS	DEG_SCF_FBW7_1	277:284	Mutation rewiring degron network	0.1667
p.L271P	SIDM00596	Endometrial Carcinoma	GDSC	PGSTPRIS	DEG_SCF_FBW7_1	277:284	Mutation rewiring degron network	0.1667
p.L271P	ACH-001517	Endometrial/Uterine Cancer	CCLE	PGSTPRIS	DEG_SCF_FBW7_1	277:284	Mutation rewiring degron network	0.1667
p.L271P	HEC-1	endometrium	COSMIC	PGSTPRIS	DEG_SCF_FBW7_1	277:284	Mutation rewiring degron network	0.1667
p.I94V	TCGA-EE-A29D	SKCM	TCGA	LGSTPLTS	DEG_SCF_FBW7_1	103:110	Mutation rewiring degron network	0.0833
p.R282M	TCGA-EE-A3AD	SKCM	TCGA	PGSTPRIS	DEG_SCF_FBW7_1	277:284	Mutation altering degron motif	0.7521
p.F120Y	DO48290	ESCA	ICGC	LGSTPLTS	DEG_SCF_FBW7_1	103:110	Mutation rewiring degron network	0.0556
p.G116V	DO229027	LICA	ICGC	LGSTPLTS	DEG_SCF_FBW7_1	103:110	Mutation rewiring degron network	0.1667
p.V109F	DO29046	OV	ICGC	LGSTPLTS	DEG_SCF_FBW7_1	103:110	Mutation altering degron motif	0.7068
p.P113T	DO37951	SKCM	ICGC	LGSTPLTS	DEG_SCF_FBW7_1	103:110	Mutation rewiring degron network	0.25
p.Q284H	DO47353	SKCM	ICGC	PGSTPRIS	DEG_SCF_FBW7_1	277:284	Mutation altering degron motif	0.7582
p.P97T	DO229272	THCA	ICGC	LGSTPLTS	DEG_SCF_FBW7_1	103:110	Mutation rewiring degron network	0.1667
p.T110A	DO39016	THCA	ICGC	LGSTPLTS	DEG_SCF_FBW7_1	103:110	Mutation altering degron motif	0.7139
p.S111P	DO42312	UCEC	ICGC	LGSTPLTS	DEG_SCF_FBW7_1	103:110	Mutation rewiring degron network	0.3056
p.Q117H	DO42312	UCEC	ICGC	LGSTPLTS	DEG_SCF_FBW7_1	103:110	Mutation rewiring degron network	0.1389
p.S287P	DO42977	UCEC	ICGC	PGSTPRIS	DEG_SCF_FBW7_1	277:284	Mutation rewiring degron network	0.25
p.I116T	SIDM00878	Breast Carcinoma	GDSC	LGSTPLTS	DEG_SCF_FBW7_1	103:110	Mutation rewiring degron network	0.1667
p.I116T	ACH-000930	Breast Cancer	CCLE	LGSTPLTS	DEG_SCF_FBW7_1	103:110	Mutation rewiring degron network	0.1667
p.I116T	HCC1569	breast	COSMIC	LGSTPLTS	DEG_SCF_FBW7_1	103:110	Mutation rewiring degron network	0.1667
p.T285I	SIDM00213	Thyroid Gland Carcinoma	GDSC	PGSTPRIS	DEG_SCF_FBW7_1	277:284	Mutation blocking phosphorylation signal	0.75
p.T285I	SIDM00228	Thyroid Gland Carcinoma	GDSC	PGSTPRIS	DEG_SCF_FBW7_1	277:284	Mutation blocking phosphorylation signal	0.75
p.T285I	ACH-000897	Thyroid Cancer	CCLE	PGSTPRIS	DEG_SCF_FBW7_1	277:284	Mutation blocking phosphorylation signal	0.75
p.T285I	ACH-000903	Thyroid Cancer	CCLE	PGSTPRIS	DEG_SCF_FBW7_1	277:284	Mutation blocking phosphorylation signal	0.75
p.L108S	ACH-000982	Colon/Colorectal Cancer	CCLE	LGSTPLTS	DEG_SCF_FBW7_1	103:110	Mutation altering degron motif	0.6556
p.I99T	HCC1569	breast	COSMIC	LGSTPLTS	DEG_SCF_FBW7_1	103:110	Mutation blocking phosphorylation signal	0.6667

Kaplan plot for NUP35 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NUP35

UniProt ID: Q8NFH5

Entrez ID: 129401

Protein name: Nucleoporin NUP35 (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44) (Nuclear pore complex protein Nup53) (Nucleoporin NUP53)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NUP35 in