DegronMD

Uniprot ID: Q8NFH5

Source protein: Nucleoporin NUP35

Source gene: NUP35

Class: DEG_SCF_FBW7_1

Location: 277:284

E3 ligase: FBXW7

DEGRON score: 0.82

ASA_SCORE: 81.6125

COIL: 0.8989

CONS_SCORE: 0.3542

DSS_SCORE: 0.6651

HELIX: 0.0515

FCONS_SCORE: 0.767

RIG_SCORE: 0.6744

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L271P	TCGA-B5-A1MX	UCEC	TCGA	PGSTPRIS	DEG_SCF_FBW7_1	0.1667
p.L271P	SIDM00596	Endometrial Carcinoma	GDSC	PGSTPRIS	DEG_SCF_FBW7_1	0.1667
p.L271P	ACH-001517	Endometrial/Uterine Cancer	CCLE	PGSTPRIS	DEG_SCF_FBW7_1	0.1667
p.L271P	HEC-1	endometrium	COSMIC	PGSTPRIS	DEG_SCF_FBW7_1	0.1667
p.R282M	TCGA-EE-A3AD	SKCM	TCGA	PGSTPRIS	DEG_SCF_FBW7_1	0.7521
p.Q284H	DO47353	SKCM	ICGC	PGSTPRIS	DEG_SCF_FBW7_1	0.7582
p.S287P	DO42977	UCEC	ICGC	PGSTPRIS	DEG_SCF_FBW7_1	0.25
p.T285I	SIDM00213	Thyroid Gland Carcinoma	GDSC	PGSTPRIS	DEG_SCF_FBW7_1	0.75
p.T285I	SIDM00228	Thyroid Gland Carcinoma	GDSC	PGSTPRIS	DEG_SCF_FBW7_1	0.75
p.T285I	ACH-000897	Thyroid Cancer	CCLE	PGSTPRIS	DEG_SCF_FBW7_1	0.75
p.T285I	ACH-000903	Thyroid Cancer	CCLE	PGSTPRIS	DEG_SCF_FBW7_1	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NFH5	Nucleoporin NUP35	DEG_SCF_FBW7_1	277:284	PGSTPRIS	FBXW7	0.82	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons