DegronMD

Uniprot ID: P54845

Source protein: Neural retina-specific leucine zipper protein

Source gene: NRL

Class: DEG_SCF_FBW7_1

Location: 39:46

E3 ligase: FBXW7

DEGRON score: 0.9919

ASA_SCORE: 70.375

COIL: 0.9336

CONS_SCORE: 0.4957

DSS_SCORE: 0.6571

HELIX: 0.0194

FCONS_SCORE: 0.8972

RIG_SCORE: 0.563

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P43H	DO228952	LICA	ICGC	LGSTPYSS	DEG_SCF_FBW7_1	0.7694
p.P43H	DO229006	LICA	ICGC	LGSTPYSS	DEG_SCF_FBW7_1	0.7694
p.S45I	DO42673	UCEC	ICGC	LGSTPYSS	DEG_SCF_FBW7_1	0.623
p.P56Q	DO229038	LICA	ICGC	LGSTPYSS	DEG_SCF_FBW7_1	0.0556

Showing 1 to 4 of 4 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54845	Neural retina-specific leucine zipper protein	DEG_SCF_FBW7_1	39:46	LGSTPYSS	FBXW7	0.9919	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons