DegronMD - P54845(NRL)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E70K	TCGA-5L-AAT1	BRCA	TCGA	TRPGLEELY	DEG_APCC_DBOX_1	65:73	Mutation altering degron motif	0.591
p.E70K	DO219594	BRCA	ICGC	TRPGLEELY	DEG_APCC_DBOX_1	65:73	Mutation altering degron motif	0.591
p.W74L	TCGA-85-8288	LUSC	TCGA	TRPGLEELY	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.3056
p.W74L	DO26963	LUSC	ICGC	TRPGLEELY	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.3056
p.L78M	TCGA-BR-6457	STAD	TCGA	TRPGLEELY	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.1944
p.L78M	DO38759	STAD	ICGC	TRPGLEELY	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.1944
p.P43H	DO228952	LICA	ICGC	LGSTPYSS	DEG_SCF_FBW7_1	39:46	Mutation altering degron motif	0.7694
p.P43H	DO229006	LICA	ICGC	LGSTPYSS	DEG_SCF_FBW7_1	39:46	Mutation altering degron motif	0.7694
p.P56Q	DO229038	LICA	ICGC	TRPGLEELY	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.0833
p.P56Q	DO229038	LICA	ICGC	LGSTPYSS	DEG_SCF_FBW7_1	39:46	Mutation rewiring degron network	0.0556
p.Q81R	DO45289	LIRI	ICGC	TRPGLEELY	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.1111
p.S45I	DO42673	UCEC	ICGC	LGSTPYSS	DEG_SCF_FBW7_1	39:46	Mutation altering degron motif	0.623
p.A76V	SIDM01103	Squamous Cell Lung Carcinoma	GDSC	TRPGLEELY	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.25
p.A76V	SK-MES-1	lung	COSMIC	TRPGLEELY	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.25
p.G57D	SIDM00660	Colorectal Carcinoma	GDSC	TRPGLEELY	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.1111
p.G57D	ACH-000985	Colon/Colorectal Cancer	CCLE	TRPGLEELY	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.1111
p.G57D	LS-411N	large intestine	COSMIC	TRPGLEELY	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.1111
p.E63K	SIDM00481	Ovarian Carcinoma	GDSC	TRPGLEELY	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.2778
p.E63K	SIDM00118	Colorectal Carcinoma	GDSC	TRPGLEELY	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.2778
p.E63K	OAW-28	ovary	COSMIC	TRPGLEELY	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.2778
p.E63K	HCC2998	large intestine	COSMIC	TRPGLEELY	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.2778
p.G83V	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	TRPGLEELY	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.0556
p.G83V	ACH-000892	Lung Cancer	CCLE	TRPGLEELY	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.0556
p.G83V	NCI-H1563	lung	COSMIC	TRPGLEELY	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.0556
p.G83R	ACH-000969	Colon/Colorectal Cancer	CCLE	TRPGLEELY	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.0556

Kaplan plot for NRL in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NRL

UniProt ID: P54845

Entrez ID: 4901

Protein name: Neural retina-specific leucine zipper protein (NRL)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NRL in