DegronMD

Uniprot ID: P54845

Source protein: Neural retina-specific leucine zipper protein

Source gene: NRL

Class: DEG_APCC_DBOX_1

Location: 65:73

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5482

ASA_SCORE: 78.0444

COIL: 0.6273

CONS_SCORE: 0.5242

DSS_SCORE: 0.4039

HELIX: 0.293

FCONS_SCORE: 1.0029

RIG_SCORE: 0.8048

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E70K	TCGA-5L-AAT1	BRCA	TCGA	TRPGLEELY	DEG_APCC_DBOX_1	0.591
p.E70K	DO219594	BRCA	ICGC	TRPGLEELY	DEG_APCC_DBOX_1	0.591
p.W74L	TCGA-85-8288	LUSC	TCGA	TRPGLEELY	DEG_APCC_DBOX_1	0.3056
p.W74L	DO26963	LUSC	ICGC	TRPGLEELY	DEG_APCC_DBOX_1	0.3056
p.L78M	TCGA-BR-6457	STAD	TCGA	TRPGLEELY	DEG_APCC_DBOX_1	0.1944
p.L78M	DO38759	STAD	ICGC	TRPGLEELY	DEG_APCC_DBOX_1	0.1944
p.P56Q	DO229038	LICA	ICGC	TRPGLEELY	DEG_APCC_DBOX_1	0.0833
p.Q81R	DO45289	LIRI	ICGC	TRPGLEELY	DEG_APCC_DBOX_1	0.1111
p.A76V	SIDM01103	Squamous Cell Lung Carcinoma	GDSC	TRPGLEELY	DEG_APCC_DBOX_1	0.25
p.A76V	SK-MES-1	lung	COSMIC	TRPGLEELY	DEG_APCC_DBOX_1	0.25
p.G57D	SIDM00660	Colorectal Carcinoma	GDSC	TRPGLEELY	DEG_APCC_DBOX_1	0.1111
p.G57D	ACH-000985	Colon/Colorectal Cancer	CCLE	TRPGLEELY	DEG_APCC_DBOX_1	0.1111
p.G57D	LS-411N	large_intestine	COSMIC	TRPGLEELY	DEG_APCC_DBOX_1	0.1111
p.E63K	SIDM00481	Ovarian Carcinoma	GDSC	TRPGLEELY	DEG_APCC_DBOX_1	0.2778
p.E63K	SIDM00118	Colorectal Carcinoma	GDSC	TRPGLEELY	DEG_APCC_DBOX_1	0.2778
p.E63K	OAW-28	ovary	COSMIC	TRPGLEELY	DEG_APCC_DBOX_1	0.2778
p.E63K	HCC2998	large_intestine	COSMIC	TRPGLEELY	DEG_APCC_DBOX_1	0.2778
p.G83V	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	TRPGLEELY	DEG_APCC_DBOX_1	0.0556
p.G83V	ACH-000892	Lung Cancer	CCLE	TRPGLEELY	DEG_APCC_DBOX_1	0.0556
p.G83V	NCI-H1563	lung	COSMIC	TRPGLEELY	DEG_APCC_DBOX_1	0.0556
p.G83R	ACH-000969	Colon/Colorectal Cancer	CCLE	TRPGLEELY	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54845	Neural retina-specific leucine zipper protein	DEG_APCC_DBOX_1	65:73	TRPGLEELY	APC,CDC20,FZR1	0.5482	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons