DegronMD

Uniprot ID: Q8WY36

Source protein: HMG box transcription factor BBX

Source gene: BBX

Class: DEG_SCF_FBW7_1

Location: 219:225

E3 ligase: FBXW7

DEGRON score: 0.9698

ASA_SCORE: 80.2571

COIL: 0.901

CONS_SCORE: 0.375

DSS_SCORE: 0.5225

HELIX: 0.0349

FCONS_SCORE: 0.7676

RIG_SCORE: 0.6467

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A218V	TCGA-B5-A11E	UCEC	TCGA	LGTPEVS	DEG_SCF_FBW7_1	0.3056
p.A218V	DO41644	UCEC	ICGC	LGTPEVS	DEG_SCF_FBW7_1	0.3056
p.D232G	TCGA-EY-A548	UCEC	TCGA	LGTPEVS	DEG_SCF_FBW7_1	0.1389
p.D232G	DO48173	UCEC	ICGC	LGTPEVS	DEG_SCF_FBW7_1	0.1389
p.P222Q	TCGA-FS-A1Z0	SKCM	TCGA	LGTPEVS	DEG_SCF_FBW7_1	0.7035
p.P222Q	DO37431	SKCM	ICGC	LGTPEVS	DEG_SCF_FBW7_1	0.7035
p.G215V	TCGA-FS-A1ZM	SKCM	TCGA	LGTPEVS	DEG_SCF_FBW7_1	0.2222
p.G215V	DO37731	SKCM	ICGC	LGTPEVS	DEG_SCF_FBW7_1	0.2222
p.V233F	DO229015	LICA	ICGC	LGTPEVS	DEG_SCF_FBW7_1	0.1111
p.M210V	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	LGTPEVS	DEG_SCF_FBW7_1	0.0833
p.M210V	ACH-000605	Esophageal Cancer	CCLE	LGTPEVS	DEG_SCF_FBW7_1	0.0833
p.M210V	TE-6	oesophagus	COSMIC	LGTPEVS	DEG_SCF_FBW7_1	0.0833
p.S209C	ACH-000844	Lung Cancer	CCLE	LGTPEVS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WY36	HMG box transcription factor BBX	DEG_SCF_FBW7_1	219:225	LGTPEVS	FBXW7	0.9698	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons