DegronMD

Uniprot ID: Q5TIE3

Source protein: von Willebrand factor A domain-containing protein 5B1

Source gene: VWA5B1

Class: DEG_SCF_FBW7_2

Location: 831:837

E3 ligase: FBXW7

DEGRON score: 0.9155

ASA_SCORE: 60.4714

COIL: 0.7526

CONS_SCORE: 0.4892

DSS_SCORE: 0.538

HELIX: 0.0226

FCONS_SCORE: 1.0179

RIG_SCORE: 0.6549

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R838L	TCGA-A5-A0VP	UCEC	TCGA	LGTPGPE	DEG_SCF_FBW7_2	0.3056
p.R838L	DO42600	UCEC	ICGC	LGTPGPE	DEG_SCF_FBW7_2	0.3056
p.D843G	TCGA-DM-A1D8	COAD	TCGA	LGTPGPE	DEG_SCF_FBW7_2	0.1667
p.D843G	DO8914	COAD	ICGC	LGTPGPE	DEG_SCF_FBW7_2	0.1667
p.P836Q	TCGA-G4-6628	COAD	TCGA	LGTPGPE	DEG_SCF_FBW7_2	0.5924
p.P836Q	DO10132	COAD	ICGC	LGTPGPE	DEG_SCF_FBW7_2	0.5924
p.E826D	DO50727	ORCA	ICGC	LGTPGPE	DEG_SCF_FBW7_2	0.1944
p.R822C	SIDM02059	Colorectal Carcinoma	GDSC	LGTPGPE	DEG_SCF_FBW7_2	0.0833
p.A841V	SIDM00121	T-Lymphoblastic Leukemia	GDSC	LGTPGPE	DEG_SCF_FBW7_2	0.2222
p.A841V	ACH-001738	Leukemia	CCLE	LGTPGPE	DEG_SCF_FBW7_2	0.2222
p.A841V	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	LGTPGPE	DEG_SCF_FBW7_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TIE3	von Willebrand factor A domain-containing protein 5B1	DEG_SCF_FBW7_2	831:837	LGTPGPE	FBXW7	0.9155	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons