DegronMD - Q5TIE3(VWA5B1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R838L	TCGA-A5-A0VP	UCEC	TCGA	LGTPGPE	DEG_SCF_FBW7_2	831:837	Mutation rewiring degron network	0.3056
p.R838L	DO42600	UCEC	ICGC	LGTPGPE	DEG_SCF_FBW7_2	831:837	Mutation rewiring degron network	0.3056
p.R327Q	TCGA-A5-A2K5	UCEC	TCGA	RKRLHKD	LIG_APCC_ABBAyCdc20_2	327:333	Mutation altering degron motif	0.7329
p.R327Q	TCGA-AX-A0J0	UCEC	TCGA	RKRLHKD	LIG_APCC_ABBAyCdc20_2	327:333	Mutation altering degron motif	0.7329
p.D843G	TCGA-DM-A1D8	COAD	TCGA	LGTPGPE	DEG_SCF_FBW7_2	831:837	Mutation rewiring degron network	0.1667
p.D843G	DO8914	COAD	ICGC	LGTPGPE	DEG_SCF_FBW7_2	831:837	Mutation rewiring degron network	0.1667
p.R329C	TCGA-EA-A439	CESC	TCGA	RKRLHKD	LIG_APCC_ABBAyCdc20_2	327:333	Mutation altering degron motif	0.719
p.R329C	SIDM02049	Pancreatic Carcinoma	GDSC	RKRLHKD	LIG_APCC_ABBAyCdc20_2	327:333	Mutation altering degron motif	0.719
p.P836Q	TCGA-G4-6628	COAD	TCGA	LGTPGPE	DEG_SCF_FBW7_2	831:837	Mutation altering degron motif	0.5924
p.P836Q	DO10132	COAD	ICGC	LGTPGPE	DEG_SCF_FBW7_2	831:837	Mutation altering degron motif	0.5924
p.S317T	DO225023	BRCA	ICGC	RKRLHKD	LIG_APCC_ABBAyCdc20_2	327:333	Mutation rewiring degron network	0.0556
p.Q326E	DO2216	BRCA	ICGC	RKRLHKD	LIG_APCC_ABBAyCdc20_2	327:333	Mutation rewiring degron network	0.3056
p.A338S	DO229029	LICA	ICGC	RKRLHKD	LIG_APCC_ABBAyCdc20_2	327:333	Mutation rewiring degron network	0.1944
p.D336Y	DO229025	LICA	ICGC	RKRLHKD	LIG_APCC_ABBAyCdc20_2	327:333	Mutation rewiring degron network	0.25
p.E826D	DO50727	ORCA	ICGC	LGTPGPE	DEG_SCF_FBW7_2	831:837	Mutation rewiring degron network	0.1944
p.S341L	DO42849	UCEC	ICGC	RKRLHKD	LIG_APCC_ABBAyCdc20_2	327:333	Mutation rewiring degron network	0.1111
p.K339N	DO41379	UCEC	ICGC	RKRLHKD	LIG_APCC_ABBAyCdc20_2	327:333	Mutation rewiring degron network	0.1667
p.R822C	SIDM02059	Colorectal Carcinoma	GDSC	LGTPGPE	DEG_SCF_FBW7_2	831:837	Mutation rewiring degron network	0.0833
p.R321W	SIDM00858	Osteosarcoma	GDSC	RKRLHKD	LIG_APCC_ABBAyCdc20_2	327:333	Mutation rewiring degron network	0.1667
p.R321W	ACH-000082	bone	CCLE	RKRLHKD	LIG_APCC_ABBAyCdc20_2	327:333	Mutation rewiring degron network	0.1667
p.R321W	G-292_Clone_A141B1	bone	COSMIC	RKRLHKD	LIG_APCC_ABBAyCdc20_2	327:333	Mutation rewiring degron network	0.1667
p.A841V	SIDM00121	T-Lymphoblastic Leukemia	GDSC	LGTPGPE	DEG_SCF_FBW7_2	831:837	Mutation rewiring degron network	0.2222
p.A841V	ACH-001738	Leukemia	CCLE	LGTPGPE	DEG_SCF_FBW7_2	831:837	Mutation rewiring degron network	0.2222
p.A841V	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	LGTPGPE	DEG_SCF_FBW7_2	831:837	Mutation rewiring degron network	0.2222
p.P335T	SIDM01205	Acute Myeloid Leukemia	GDSC	RKRLHKD	LIG_APCC_ABBAyCdc20_2	327:333	Mutation rewiring degron network	0.2778
p.P335T	ACH-002314	Leukemia	CCLE	RKRLHKD	LIG_APCC_ABBAyCdc20_2	327:333	Mutation rewiring degron network	0.2778
p.P335T	TUR	haematopoietic and lymphoid tissue	COSMIC	RKRLHKD	LIG_APCC_ABBAyCdc20_2	327:333	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VWA5B1

UniProt ID: Q5TIE3

Entrez ID: 127731

Protein name: von Willebrand factor A domain-containing protein 5B1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for VWA5B1 in