DegronMD

Uniprot ID: Q5TIE3

Source protein: von Willebrand factor A domain-containing protein 5B1

Source gene: VWA5B1

Class: LIG_APCC_ABBAyCdc20_2

Location: 327:333

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5919

ASA_SCORE: 104.6286

COIL: 0.5881

CONS_SCORE: 0.5739

DSS_SCORE: 0.3862

HELIX: 0.2724

FCONS_SCORE: 1.0427

RIG_SCORE: 0.7618

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R327Q	TCGA-A5-A2K5	UCEC	TCGA	RKRLHKD	LIG_APCC_ABBAyCdc20_2	0.7329
p.R327Q	TCGA-AX-A0J0	UCEC	TCGA	RKRLHKD	LIG_APCC_ABBAyCdc20_2	0.7329
p.R329C	TCGA-EA-A439	CESC	TCGA	RKRLHKD	LIG_APCC_ABBAyCdc20_2	0.719
p.R329C	SIDM02049	Pancreatic Carcinoma	GDSC	RKRLHKD	LIG_APCC_ABBAyCdc20_2	0.719
p.S317T	DO225023	BRCA	ICGC	RKRLHKD	LIG_APCC_ABBAyCdc20_2	0.0556
p.Q326E	DO2216	BRCA	ICGC	RKRLHKD	LIG_APCC_ABBAyCdc20_2	0.3056
p.A338S	DO229029	LICA	ICGC	RKRLHKD	LIG_APCC_ABBAyCdc20_2	0.1944
p.D336Y	DO229025	LICA	ICGC	RKRLHKD	LIG_APCC_ABBAyCdc20_2	0.25
p.S341L	DO42849	UCEC	ICGC	RKRLHKD	LIG_APCC_ABBAyCdc20_2	0.1111
p.K339N	DO41379	UCEC	ICGC	RKRLHKD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R321W	SIDM00858	Osteosarcoma	GDSC	RKRLHKD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R321W	ACH-000082	bone	CCLE	RKRLHKD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R321W	G-292_Clone_A141B1	bone	COSMIC	RKRLHKD	LIG_APCC_ABBAyCdc20_2	0.1667
p.P335T	SIDM01205	Acute Myeloid Leukemia	GDSC	RKRLHKD	LIG_APCC_ABBAyCdc20_2	0.2778
p.P335T	ACH-002314	Leukemia	CCLE	RKRLHKD	LIG_APCC_ABBAyCdc20_2	0.2778
p.P335T	TUR	haematopoietic_and_lymphoid_tissue	COSMIC	RKRLHKD	LIG_APCC_ABBAyCdc20_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TIE3	von Willebrand factor A domain-containing protein 5B1	LIG_APCC_ABBAyCdc20_2	327:333	RKRLHKD	APC,CDC20,FZR1	0.5919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons