DegronMD

Uniprot ID: Q99062

Source protein: Granulocyte colony-stimulating factor receptor

Source gene: CSF3R

Class: DEG_SCF_FBW7_1

Location: 688:694

E3 ligase: FBXW7

DEGRON score: 0.994

ASA_SCORE: 73.0429

COIL: 0.8943

CONS_SCORE: 0.4249

DSS_SCORE: 0.4782

HELIX: 0.0103

FCONS_SCORE: 0.9185

RIG_SCORE: 0.7216

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P704S	TCGA-19-5956	GBM	TCGA	LGTPPIT	DEG_SCF_FBW7_1	0.5
p.P704S	TCGA-ER-A193	SKCM	TCGA	LGTPPIT	DEG_SCF_FBW7_1	0.5
p.P704S	DO13863	GBM	ICGC	LGTPPIT	DEG_SCF_FBW7_1	0.5
p.P704S	DO47368	SKCM	ICGC	LGTPPIT	DEG_SCF_FBW7_1	0.5
p.P704T	TCGA-EY-A215	UCEC	TCGA	LGTPPIT	DEG_SCF_FBW7_1	0.5
p.P704T	DO42665	UCEC	ICGC	LGTPPIT	DEG_SCF_FBW7_1	0.5
p.E679K	TCGA-G2-AA3B	BLCA	TCGA	LGTPPIT	DEG_SCF_FBW7_1	0.0833
p.M678I	TCGA-GN-A26C	SKCM	TCGA	LGTPPIT	DEG_SCF_FBW7_1	0.0556
p.P684L	TCGA-W3-A824	SKCM	TCGA	LGTPPIT	DEG_SCF_FBW7_1	0.2222
p.P684L	DO51271	SKCM	ICGC	LGTPPIT	DEG_SCF_FBW7_1	0.2222
p.E700Q	DO44377	CESC	ICGC	LGTPPIT	DEG_SCF_FBW7_1	0.1667
p.T690M	DO12460	GBM	ICGC	LGTPPIT	DEG_SCF_FBW7_1	0.7423
p.S693Y	DO229031	LICA	ICGC	LGTPPIT	DEG_SCF_FBW7_1	0.712
p.A682T	DO31789	OV	ICGC	LGTPPIT	DEG_SCF_FBW7_1	0.1667
p.E679A	DO47104	RECA	ICGC	LGTPPIT	DEG_SCF_FBW7_1	0.0833
p.L685P	DO41799	UCEC	ICGC	LGTPPIT	DEG_SCF_FBW7_1	0.25
p.T693I	SIDM01293	Colorectal Carcinoma	GDSC	LGTPPIT	DEG_SCF_FBW7_1	0.7078
p.M696T	SIDM01058	B-Cell Non-Hodgkin's Lymphoma	GDSC	LGTPPIT	DEG_SCF_FBW7_1	0.2778
p.M696T	SIDM00962	Chronic Myelogenous Leukemia	GDSC	LGTPPIT	DEG_SCF_FBW7_1	0.2778
p.M696T	SIDM00919	Ovarian Carcinoma	GDSC	LGTPPIT	DEG_SCF_FBW7_1	0.2778
p.M696T	SIDM00007	Other Solid Cancers	GDSC	LGTPPIT	DEG_SCF_FBW7_1	0.2778
p.M696T	SIDM00402	Bladder Carcinoma	GDSC	LGTPPIT	DEG_SCF_FBW7_1	0.2778
p.M696T	SIDM01118	Small Cell Lung Carcinoma	GDSC	LGTPPIT	DEG_SCF_FBW7_1	0.2778
p.M696T	SIDM00801	Melanoma	GDSC	LGTPPIT	DEG_SCF_FBW7_1	0.2778
p.M696T	SIDM00049	Colorectal Carcinoma	GDSC	LGTPPIT	DEG_SCF_FBW7_1	0.2778
p.M696T	SIDM00182	Head and Neck Carcinoma	GDSC	LGTPPIT	DEG_SCF_FBW7_1	0.2778
p.M696T	SIDM00814	Other Solid Cancers	GDSC	LGTPPIT	DEG_SCF_FBW7_1	0.2778
p.M696T	SIDM01564	Colorectal Carcinoma	GDSC	LGTPPIT	DEG_SCF_FBW7_1	0.2778
p.R698C	SIDM01010	T-Cell Non-Hodgkin's Lymphoma	GDSC	LGTPPIT	DEG_SCF_FBW7_1	0.2222
p.D702G	ACH-000998	Colon/Colorectal Cancer	CCLE	LGTPPIT	DEG_SCF_FBW7_1	0.1111
p.D702G	CW-2	large_intestine	COSMIC	LGTPPIT	DEG_SCF_FBW7_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LGTPPIT

Degron related mutations and impact score

Drug responses associated with CSF3R mutations

All proteins holding degron of LGTPPIT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99062	Granulocyte colony-stimulating factor receptor	DEG_SCF_FBW7_1	688:694	LGTPPIT	FBXW7	0.994	More...