DegronMD - Q99062(CSF3R)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P704S	TCGA-19-5956	GBM	TCGA	LGTPPIT	DEG_SCF_FBW7_1	688:694	Mutation blocking ubiquitination signal	0.5
p.P704S	TCGA-ER-A193	SKCM	TCGA	LGTPPIT	DEG_SCF_FBW7_1	688:694	Mutation blocking ubiquitination signal	0.5
p.P704S	DO13863	GBM	ICGC	LGTPPIT	DEG_SCF_FBW7_1	688:694	Mutation blocking ubiquitination signal	0.5
p.P704S	DO47368	SKCM	ICGC	LGTPPIT	DEG_SCF_FBW7_1	688:694	Mutation blocking ubiquitination signal	0.5
p.R796C	TCGA-AX-A2HD	UCEC	TCGA	LVTPAPS	DEG_SCF_FBW7_1	800:806	Mutation rewiring degron network	0.2222
p.R796C	SIDM00303	Ovarian Carcinoma	GDSC	LVTPAPS	DEG_SCF_FBW7_1	800:806	Mutation rewiring degron network	0.2222
p.R796C	JHOS-4	ovary	COSMIC	LVTPAPS	DEG_SCF_FBW7_1	800:806	Mutation rewiring degron network	0.2222
p.A805V	TCGA-B5-A11Y	UCEC	TCGA	LVTPAPS	DEG_SCF_FBW7_1	800:806	Mutation altering degron motif	0.6936
p.A805V	SIDM00781	Colorectal Carcinoma	GDSC	LVTPAPS	DEG_SCF_FBW7_1	800:806	Mutation altering degron motif	0.6936
p.A805V	SIDM00780	Colorectal Carcinoma	GDSC	LVTPAPS	DEG_SCF_FBW7_1	800:806	Mutation altering degron motif	0.6936
p.A805V	SNU-C2B	large intestine	COSMIC	LVTPAPS	DEG_SCF_FBW7_1	800:806	Mutation altering degron motif	0.6936
p.K812E	TCGA-CG-4305	STAD	TCGA	LVTPAPS	DEG_SCF_FBW7_1	800:806	Mutation rewiring degron network	0.1667
p.P704T	TCGA-EY-A215	UCEC	TCGA	LGTPPIT	DEG_SCF_FBW7_1	688:694	Mutation blocking ubiquitination signal	0.5
p.P704T	DO42665	UCEC	ICGC	LGTPPIT	DEG_SCF_FBW7_1	688:694	Mutation blocking ubiquitination signal	0.5
p.P809L	TCGA-FS-A4FC	SKCM	TCGA	LVTPAPS	DEG_SCF_FBW7_1	800:806	Mutation rewiring degron network	0.25
p.E679K	TCGA-G2-AA3B	BLCA	TCGA	LGTPPIT	DEG_SCF_FBW7_1	688:694	Mutation rewiring degron network	0.0833
p.M678I	TCGA-GN-A26C	SKCM	TCGA	LGTPPIT	DEG_SCF_FBW7_1	688:694	Mutation rewiring degron network	0.0556
p.P684L	TCGA-W3-A824	SKCM	TCGA	LGTPPIT	DEG_SCF_FBW7_1	688:694	Mutation rewiring degron network	0.2222
p.P684L	DO51271	SKCM	ICGC	LGTPPIT	DEG_SCF_FBW7_1	688:694	Mutation rewiring degron network	0.2222
p.T799S	DO5465	BRCA	ICGC	LVTPAPS	DEG_SCF_FBW7_1	800:806	Mutation rewiring degron network	0.3056
p.E700Q	DO44377	CESC	ICGC	LGTPPIT	DEG_SCF_FBW7_1	688:694	Mutation rewiring degron network	0.1667
p.A804V	DO233258	GACA	ICGC	LVTPAPS	DEG_SCF_FBW7_1	800:806	Mutation altering degron motif	0.5825
p.T690M	DO12460	GBM	ICGC	LGTPPIT	DEG_SCF_FBW7_1	688:694	Mutation altering degron motif	0.7423
p.Q793K	DO228943	LICA	ICGC	LVTPAPS	DEG_SCF_FBW7_1	800:806	Mutation rewiring degron network	0.1389
p.Q793K	DO229037	LICA	ICGC	LVTPAPS	DEG_SCF_FBW7_1	800:806	Mutation rewiring degron network	0.1389
p.S693Y	DO229031	LICA	ICGC	LGTPPIT	DEG_SCF_FBW7_1	688:694	Mutation altering degron motif	0.712
p.A682T	DO31789	OV	ICGC	LGTPPIT	DEG_SCF_FBW7_1	688:694	Mutation rewiring degron network	0.1667
p.P815S	DO232761	PBCA	ICGC	LVTPAPS	DEG_SCF_FBW7_1	800:806	Mutation rewiring degron network	0.0833
p.E679A	DO47104	RECA	ICGC	LGTPPIT	DEG_SCF_FBW7_1	688:694	Mutation rewiring degron network	0.0833
p.P803T	DO37447	SKCM	ICGC	LVTPAPS	DEG_SCF_FBW7_1	800:806	Mutation altering degron motif	0.7031
p.L790F	DO50284	SKCM	ICGC	LVTPAPS	DEG_SCF_FBW7_1	800:806	Mutation rewiring degron network	0.0556
p.V812F	DO38467	STAD	ICGC	LVTPAPS	DEG_SCF_FBW7_1	800:806	Mutation rewiring degron network	0.1667
p.L685P	DO41799	UCEC	ICGC	LGTPPIT	DEG_SCF_FBW7_1	688:694	Mutation rewiring degron network	0.25
p.T693I	SIDM01293	Colorectal Carcinoma	GDSC	LGTPPIT	DEG_SCF_FBW7_1	688:694	Mutation altering degron motif	0.7078
p.M696T	SIDM01058	B-Cell Non-Hodgkin's Lymphoma	GDSC	LGTPPIT	DEG_SCF_FBW7_1	688:694	Mutation rewiring degron network	0.2778
p.M696T	SIDM00962	Chronic Myelogenous Leukemia	GDSC	LGTPPIT	DEG_SCF_FBW7_1	688:694	Mutation rewiring degron network	0.2778
p.M696T	SIDM00919	Ovarian Carcinoma	GDSC	LGTPPIT	DEG_SCF_FBW7_1	688:694	Mutation rewiring degron network	0.2778
p.M696T	SIDM00007	Other Solid Cancers	GDSC	LGTPPIT	DEG_SCF_FBW7_1	688:694	Mutation rewiring degron network	0.2778
p.M696T	SIDM00402	Bladder Carcinoma	GDSC	LGTPPIT	DEG_SCF_FBW7_1	688:694	Mutation rewiring degron network	0.2778
p.M696T	SIDM01118	Small Cell Lung Carcinoma	GDSC	LGTPPIT	DEG_SCF_FBW7_1	688:694	Mutation rewiring degron network	0.2778
p.M696T	SIDM00801	Melanoma	GDSC	LGTPPIT	DEG_SCF_FBW7_1	688:694	Mutation rewiring degron network	0.2778
p.M696T	SIDM00049	Colorectal Carcinoma	GDSC	LGTPPIT	DEG_SCF_FBW7_1	688:694	Mutation rewiring degron network	0.2778
p.M696T	SIDM00182	Head and Neck Carcinoma	GDSC	LGTPPIT	DEG_SCF_FBW7_1	688:694	Mutation rewiring degron network	0.2778
p.M696T	SIDM00814	Other Solid Cancers	GDSC	LGTPPIT	DEG_SCF_FBW7_1	688:694	Mutation rewiring degron network	0.2778
p.M696T	SIDM01564	Colorectal Carcinoma	GDSC	LGTPPIT	DEG_SCF_FBW7_1	688:694	Mutation rewiring degron network	0.2778
p.Y794C	SIDM01259	B-Lymphoblastic Leukemia	GDSC	LVTPAPS	DEG_SCF_FBW7_1	800:806	Mutation rewiring degron network	0.1667
p.Y794C	GR-ST	haematopoietic and lymphoid tissue	COSMIC	LVTPAPS	DEG_SCF_FBW7_1	800:806	Mutation rewiring degron network	0.1667
p.R698C	SIDM01010	T-Cell Non-Hodgkin's Lymphoma	GDSC	LGTPPIT	DEG_SCF_FBW7_1	688:694	Mutation rewiring degron network	0.2222
p.A794D	ACH-000712	Lung Cancer	CCLE	LVTPAPS	DEG_SCF_FBW7_1	800:806	Mutation rewiring degron network	0.1667
p.D702G	ACH-000998	Colon/Colorectal Cancer	CCLE	LGTPPIT	DEG_SCF_FBW7_1	688:694	Mutation rewiring degron network	0.1111
p.D702G	CW-2	large intestine	COSMIC	LGTPPIT	DEG_SCF_FBW7_1	688:694	Mutation rewiring degron network	0.1111

Kaplan plot for CSF3R in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CSF3R

UniProt ID: Q99062

Entrez ID: 1441

Protein name: Granulocyte colony-stimulating factor receptor (G-CSF receptor) (G-CSF-R) (CD antigen CD114)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CSF3R in