DegronMD

Uniprot ID: Q99062

Source protein: Granulocyte colony-stimulating factor receptor

Source gene: CSF3R

Class: DEG_SCF_FBW7_1

Location: 800:806

E3 ligase: FBXW7

DEGRON score: 0.9763

ASA_SCORE: 73.4

COIL: 0.8754

CONS_SCORE: 0.3883

DSS_SCORE: 0.3487

HELIX: 0.0431

FCONS_SCORE: 0.8556

RIG_SCORE: 0.7324

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R796C	TCGA-AX-A2HD	UCEC	TCGA	LVTPAPS	DEG_SCF_FBW7_1	0.2222
p.R796C	SIDM00303	Ovarian Carcinoma	GDSC	LVTPAPS	DEG_SCF_FBW7_1	0.2222
p.R796C	JHOS-4	ovary	COSMIC	LVTPAPS	DEG_SCF_FBW7_1	0.2222
p.A805V	TCGA-B5-A11Y	UCEC	TCGA	LVTPAPS	DEG_SCF_FBW7_1	0.6936
p.A805V	SIDM00781	Colorectal Carcinoma	GDSC	LVTPAPS	DEG_SCF_FBW7_1	0.6936
p.A805V	SIDM00780	Colorectal Carcinoma	GDSC	LVTPAPS	DEG_SCF_FBW7_1	0.6936
p.A805V	SNU-C2B	large_intestine	COSMIC	LVTPAPS	DEG_SCF_FBW7_1	0.6936
p.K812E	TCGA-CG-4305	STAD	TCGA	LVTPAPS	DEG_SCF_FBW7_1	0.1667
p.P809L	TCGA-FS-A4FC	SKCM	TCGA	LVTPAPS	DEG_SCF_FBW7_1	0.25
p.T799S	DO5465	BRCA	ICGC	LVTPAPS	DEG_SCF_FBW7_1	0.3056
p.A804V	DO233258	GACA	ICGC	LVTPAPS	DEG_SCF_FBW7_1	0.5825
p.Q793K	DO228943	LICA	ICGC	LVTPAPS	DEG_SCF_FBW7_1	0.1389
p.Q793K	DO229037	LICA	ICGC	LVTPAPS	DEG_SCF_FBW7_1	0.1389
p.P815S	DO232761	PBCA	ICGC	LVTPAPS	DEG_SCF_FBW7_1	0.0833
p.P803T	DO37447	SKCM	ICGC	LVTPAPS	DEG_SCF_FBW7_1	0.7031
p.L790F	DO50284	SKCM	ICGC	LVTPAPS	DEG_SCF_FBW7_1	0.0556
p.V812F	DO38467	STAD	ICGC	LVTPAPS	DEG_SCF_FBW7_1	0.1667
p.Y794C	SIDM01259	B-Lymphoblastic Leukemia	GDSC	LVTPAPS	DEG_SCF_FBW7_1	0.1667
p.Y794C	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	LVTPAPS	DEG_SCF_FBW7_1	0.1667
p.A794D	ACH-000712	Lung Cancer	CCLE	LVTPAPS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99062	Granulocyte colony-stimulating factor receptor	DEG_SCF_FBW7_1	800:806	LVTPAPS	FBXW7	0.9763	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons