DegronMD

Uniprot ID: O15400

Source protein: Syntaxin-7

Source gene: STX7

Class: DEG_SCF_FBW7_1

Location: 39:45

E3 ligase: FBXW7

DEGRON score: 0.9606

ASA_SCORE: 74.6

COIL: 0.9037

CONS_SCORE: 0.413

DSS_SCORE: 0.5566

HELIX: 0.0911

FCONS_SCORE: 0.9982

RIG_SCORE: 0.6673

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R34I	TCGA-A5-A1OF	UCEC	TCGA	LGTPQDS	DEG_SCF_FBW7_1	0.1944
p.R34I	TCGA-AA-A00N	COAD	TCGA	LGTPQDS	DEG_SCF_FBW7_1	0.1944
p.R34I	TCGA-AP-A059	UCEC	TCGA	LGTPQDS	DEG_SCF_FBW7_1	0.1944
p.R34I	DO9876	COAD	ICGC	LGTPQDS	DEG_SCF_FBW7_1	0.1944
p.R34I	DO42568	UCEC	ICGC	LGTPQDS	DEG_SCF_FBW7_1	0.1944
p.R34I	DO41361	UCEC	ICGC	LGTPQDS	DEG_SCF_FBW7_1	0.1944
p.D44Y	TCGA-AJ-A3EL	UCEC	TCGA	LGTPQDS	DEG_SCF_FBW7_1	0.6214
p.D44Y	DO41542	UCEC	ICGC	LGTPQDS	DEG_SCF_FBW7_1	0.6214
p.I32T	TCGA-B5-A3FC	UCEC	TCGA	LGTPQDS	DEG_SCF_FBW7_1	0.1389
p.I32T	DO41871	UCEC	ICGC	LGTPQDS	DEG_SCF_FBW7_1	0.1389
p.L39F	DO8264	COAD	ICGC	LGTPQDS	DEG_SCF_FBW7_1	0.6981
p.E31A	SIDM00424	B-Cell Non-Hodgkin's Lymphoma	GDSC	LGTPQDS	DEG_SCF_FBW7_1	0.1111
p.E31A	ACH-001680	Lymphoma	CCLE	LGTPQDS	DEG_SCF_FBW7_1	0.1111
p.E31A	U-698-M	haematopoietic_and_lymphoid_tissue	COSMIC	LGTPQDS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15400	Syntaxin-7	DEG_SCF_FBW7_1	39:45	LGTPQDS	FBXW7	0.9606	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons