DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SCF_FBW7_1

Location: 350:356

E3 ligase: FBXW7

DEGRON score: 0.9426

ASA_SCORE: 83.6857

COIL: 0.9211

CONS_SCORE: 0

DSS_SCORE: 0.4509

HELIX: 0.016

FCONS_SCORE: 0

RIG_SCORE: 0.6752

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S348F	TCGA-3N-A9WC	SKCM	TCGA	LGTPSIS	DEG_SCF_FBW7_1	0.2778
p.S348F	TCGA-BF-AAP0	SKCM	TCGA	LGTPSIS	DEG_SCF_FBW7_1	0.2778
p.S348F	TCGA-EE-A3AC	SKCM	TCGA	LGTPSIS	DEG_SCF_FBW7_1	0.2778
p.S348F	DO220889	MELA	ICGC	LGTPSIS	DEG_SCF_FBW7_1	0.2778
p.S348F	DO222644	MELA	ICGC	LGTPSIS	DEG_SCF_FBW7_1	0.2778
p.S348F	DO37631	SKCM	ICGC	LGTPSIS	DEG_SCF_FBW7_1	0.2778
p.S348F	DO51234	SKCM	ICGC	LGTPSIS	DEG_SCF_FBW7_1	0.2778
p.S348F	DO219462	SKCM	ICGC	LGTPSIS	DEG_SCF_FBW7_1	0.2778
p.S348F	SIDM01750	Melanoma	GDSC	LGTPSIS	DEG_SCF_FBW7_1	0.2778
p.S348F	ACH-000801	Skin Cancer	CCLE	LGTPSIS	DEG_SCF_FBW7_1	0.2778
p.K358N	TCGA-AA-A00N	COAD	TCGA	LGTPSIS	DEG_SCF_FBW7_1	0.2778
p.K358N	DO9876	COAD	ICGC	LGTPSIS	DEG_SCF_FBW7_1	0.2778
p.E341K	TCGA-AJ-A3EL	UCEC	TCGA	LGTPSIS	DEG_SCF_FBW7_1	0.0833
p.E341K	TCGA-BR-6802	STAD	TCGA	LGTPSIS	DEG_SCF_FBW7_1	0.0833
p.E341K	DO230313	COCA	ICGC	LGTPSIS	DEG_SCF_FBW7_1	0.0833
p.E341K	DO219878	SKCA	ICGC	LGTPSIS	DEG_SCF_FBW7_1	0.0833
p.E341K	DO38332	STAD	ICGC	LGTPSIS	DEG_SCF_FBW7_1	0.0833
p.E341K	DO41542	UCEC	ICGC	LGTPSIS	DEG_SCF_FBW7_1	0.0833
p.A361S	TCGA-AP-A0LM	UCEC	TCGA	LGTPSIS	DEG_SCF_FBW7_1	0.1944
p.A361S	DO43306	UCEC	ICGC	LGTPSIS	DEG_SCF_FBW7_1	0.1944
p.S356P	TCGA-BG-A0LX	UCEC	TCGA	LGTPSIS	DEG_SCF_FBW7_1	0.6752
p.S356P	DO41919	UCEC	ICGC	LGTPSIS	DEG_SCF_FBW7_1	0.6752
p.R342K	TCGA-EE-A29N	SKCM	TCGA	LGTPSIS	DEG_SCF_FBW7_1	0.1111
p.R342K	DO38001	SKCM	ICGC	LGTPSIS	DEG_SCF_FBW7_1	0.1111
p.R342K	SIDM01175	Other Sarcomas	GDSC	LGTPSIS	DEG_SCF_FBW7_1	0.1111
p.R342K	ACH-002309	Sarcoma	CCLE	LGTPSIS	DEG_SCF_FBW7_1	0.1111
p.R342K	SW684	soft_tissue	COSMIC	LGTPSIS	DEG_SCF_FBW7_1	0.1111
p.L365F	TCGA-EE-A3AC	SKCM	TCGA	LGTPSIS	DEG_SCF_FBW7_1	0.0833
p.L365F	DO37631	SKCM	ICGC	LGTPSIS	DEG_SCF_FBW7_1	0.0833
p.A340V	TCGA-EI-6917	READ	TCGA	LGTPSIS	DEG_SCF_FBW7_1	0.0556
p.A340V	DO36881	READ	ICGC	LGTPSIS	DEG_SCF_FBW7_1	0.0556
p.S356F	TCGA-IH-A3EA	SKCM	TCGA	LGTPSIS	DEG_SCF_FBW7_1	0.7982
p.S356F	DO37667	SKCM	ICGC	LGTPSIS	DEG_SCF_FBW7_1	0.7982
p.T346I	TCGA-ZF-A9RC	BLCA	TCGA	LGTPSIS	DEG_SCF_FBW7_1	0.2222
p.T346I	DO219068	BLCA	ICGC	LGTPSIS	DEG_SCF_FBW7_1	0.2222
p.R344K	DO228483	BRCA	ICGC	LGTPSIS	DEG_SCF_FBW7_1	0.1667
p.R344K	DO229010	COCA	ICGC	LGTPSIS	DEG_SCF_FBW7_1	0.1667
p.R344K	DO229013	COCA	ICGC	LGTPSIS	DEG_SCF_FBW7_1	0.1667
p.R344K	DO230550	LUSC	ICGC	LGTPSIS	DEG_SCF_FBW7_1	0.1667
p.R344K	DO52365	LUSC	ICGC	LGTPSIS	DEG_SCF_FBW7_1	0.1667
p.I364M	DO48270	ESCA	ICGC	LGTPSIS	DEG_SCF_FBW7_1	0.1111
p.L365R	DO233170	GACA	ICGC	LGTPSIS	DEG_SCF_FBW7_1	0.0833
p.T357R	DO45127	LIRI	ICGC	LGTPSIS	DEG_SCF_FBW7_1	0.3056
p.S354T	SIDM00870	Breast Carcinoma	GDSC	LGTPSIS	DEG_SCF_FBW7_1	0.6005
p.S354T	ACH-000725	Breast Cancer	CCLE	LGTPSIS	DEG_SCF_FBW7_1	0.6005
p.S354T	ACH-001068	Lymphoma	CCLE	LGTPSIS	DEG_SCF_FBW7_1	0.6005
p.S354T	HCC202	breast	COSMIC	LGTPSIS	DEG_SCF_FBW7_1	0.6005

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LGTPSIS

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of LGTPSIS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SCF_FBW7_1	350:356	LGTPSIS	FBXW7	0.9426	More...