DegronMD

Uniprot ID: Q6W4X9

Source protein: Mucin-6

Source gene: MUC6

Class: DEG_SCF_FBW7_1

Location: 2338:2344

E3 ligase: FBXW7

DEGRON score: 0.854

ASA_SCORE: 75.6286

COIL: 0.8489

CONS_SCORE: 0.1807

DSS_SCORE: 0.5201

HELIX: 0.0196

FCONS_SCORE: 0.9046

RIG_SCORE: 0.5978

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T2342M	TCGA-4R-AA8I	LIHC	TCGA	LGTPTPT	DEG_SCF_FBW7_1	0.6312
p.T2342M	DO49657	LIHC	ICGC	LGTPTPT	DEG_SCF_FBW7_1	0.6312
p.P2346H	TCGA-BR-4201	STAD	TCGA	LGTPTPT	DEG_SCF_FBW7_1	0.2778
p.P2346H	DO38707	STAD	ICGC	LGTPTPT	DEG_SCF_FBW7_1	0.2778
p.R2352W	DO230334	COCA	ICGC	LGTPTPT	DEG_SCF_FBW7_1	0.1111
p.S2336F	DO233103	GACA	ICGC	LGTPTPT	DEG_SCF_FBW7_1	0.2778
p.P2334L	DO233764	GACA	ICGC	LGTPTPT	DEG_SCF_FBW7_1	0.2222
p.G2339R	SIDM01664	Prostate Carcinoma	GDSC	LGTPTPT	DEG_SCF_FBW7_1	0.6457
p.G2339R	SIDM01347	Ovarian Carcinoma	GDSC	LGTPTPT	DEG_SCF_FBW7_1	0.6457

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6W4X9	Mucin-6	DEG_SCF_FBW7_1	2338:2344	LGTPTPT	FBXW7	0.854	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons