DegronMD

Uniprot ID: Q13724

Source protein: Mannosyl-oligosaccharide glucosidase

Source gene: MOGS

Class: LIG_APCC_ABBA_1

Location: 649:654

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.665

ASA_SCORE: 28.0667

COIL: 0.5075

CONS_SCORE: 0.6313

DSS_SCORE: 0.2599

HELIX: 0.1465

FCONS_SCORE: 1.2513

RIG_SCORE: 0.7782

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A646V	TCGA-62-A46P	LUAD	TCGA	LGVFAD	LIG_APCC_ABBA_1	0.25
p.E642Q	TCGA-63-A5MH	LUSC	TCGA	LGVFAD	LIG_APCC_ABBA_1	0.1389
p.G656V	TCGA-BF-A1Q0	SKCM	TCGA	LGVFAD	LIG_APCC_ABBA_1	0.2778
p.H644Y	TCGA-ND-A4WC	UCS	TCGA	LGVFAD	LIG_APCC_ABBA_1	0.1944
p.R645W	DO223732	CESC	ICGC	LGVFAD	LIG_APCC_ABBA_1	0.2222
p.R645W	DO233270	GACA	ICGC	LGVFAD	LIG_APCC_ABBA_1	0.2222
p.A656T	DO47817	STAD	ICGC	LGVFAD	LIG_APCC_ABBA_1	0.2778
p.A647V	LNCaP-Clone-FGC	prostate	COSMIC	LGVFAD	LIG_APCC_ABBA_1	0.2778
p.L660R	NCI-SNU-1	stomach	COSMIC	LGVFAD	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13724	Mannosyl-oligosaccharide glucosidase	LIG_APCC_ABBA_1	649:654	LGVFAD	APC,CDC20,FZR1	0.665	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons