DegronMD

Uniprot ID: Q6PL18

Source protein: ATPase family AAA domain-containing protein 2

Source gene: ATAD2

Class: LIG_APCC_ABBA_1

Location: 205:210

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9006

ASA_SCORE: 101.0167

COIL: 0.7797

CONS_SCORE: 0.217

DSS_SCORE: 0.4873

HELIX: 0.195

FCONS_SCORE: 0.8987

RIG_SCORE: 0.7349

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R195C	TCGA-4R-AA8I	LIHC	TCGA	LGVFNE	LIG_APCC_ABBA_1	0.0556
p.R195C	TCGA-AX-A06F	UCEC	TCGA	LGVFNE	LIG_APCC_ABBA_1	0.0556
p.R195C	TCGA-EO-A3B0	UCEC	TCGA	LGVFNE	LIG_APCC_ABBA_1	0.0556
p.R195C	DO49657	LIHC	ICGC	LGVFNE	LIG_APCC_ABBA_1	0.0556
p.R195C	DO219773	UCEC	ICGC	LGVFNE	LIG_APCC_ABBA_1	0.0556
p.R195C	DO41752	UCEC	ICGC	LGVFNE	LIG_APCC_ABBA_1	0.0556
p.R195C	SIDM00948	Burkitt's Lymphoma	GDSC	LGVFNE	LIG_APCC_ABBA_1	0.0556
p.R195C	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	LGVFNE	LIG_APCC_ABBA_1	0.0556
p.R195L	TCGA-64-1679	LUAD	TCGA	LGVFNE	LIG_APCC_ABBA_1	0.0556
p.R195L	DO26200	LUAD	ICGC	LGVFNE	LIG_APCC_ABBA_1	0.0556
p.N209K	TCGA-AB-2834	LAML	TCGA	LGVFNE	LIG_APCC_ABBA_1	0.5806
p.N209K	DO21749	LAML	ICGC	LGVFNE	LIG_APCC_ABBA_1	0.5806
p.E203K	TCGA-C8-A26Y	BRCA	TCGA	LGVFNE	LIG_APCC_ABBA_1	0.2778
p.E203K	DO1273	BRCA	ICGC	LGVFNE	LIG_APCC_ABBA_1	0.2778
p.E203Q	TCGA-GC-A3WC	BLCA	TCGA	LGVFNE	LIG_APCC_ABBA_1	0.2778
p.E203Q	DO755	BLCA	ICGC	LGVFNE	LIG_APCC_ABBA_1	0.2778
p.T211P	TCGA-VQ-A91X	STAD	TCGA	LGVFNE	LIG_APCC_ABBA_1	0.75
p.T211P	DO51790	STAD	ICGC	LGVFNE	LIG_APCC_ABBA_1	0.75
p.D204E	DO229041	LICA	ICGC	LGVFNE	LIG_APCC_ABBA_1	0.3056
p.L202I	DO229045	LICA	ICGC	LGVFNE	LIG_APCC_ABBA_1	0.25
p.V207M	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	LGVFNE	LIG_APCC_ABBA_1	0.6097
p.V207M	ACH-000917	Esophageal Cancer	CCLE	LGVFNE	LIG_APCC_ABBA_1	0.6097
p.V207M	TE-4	oesophagus	COSMIC	LGVFNE	LIG_APCC_ABBA_1	0.6097
p.R198Q	SIDM00929	Chondrosarcoma	GDSC	LGVFNE	LIG_APCC_ABBA_1	0.1389
p.R198Q	CAL-78	bone	COSMIC	LGVFNE	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PL18	ATPase family AAA domain-containing protein 2	LIG_APCC_ABBA_1	205:210	LGVFNE	APC,CDC20,FZR1	0.9006	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons