DegronMD - Q6PL18(ATAD2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S767Y	TCGA-19-5956	GBM	TCGA	SDDDVPSV	DEG_COP1_1	751:758	Mutation rewiring degron network	0.0833
p.S767Y	DO13863	GBM	ICGC	SDDDVPSV	DEG_COP1_1	751:758	Mutation rewiring degron network	0.0833
p.R195C	TCGA-4R-AA8I	LIHC	TCGA	LGVFNE	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.0556
p.R195C	TCGA-AX-A06F	UCEC	TCGA	LGVFNE	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.0556
p.R195C	TCGA-EO-A3B0	UCEC	TCGA	LGVFNE	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.0556
p.R195C	DO49657	LIHC	ICGC	LGVFNE	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.0556
p.R195C	DO219773	UCEC	ICGC	LGVFNE	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.0556
p.R195C	DO41752	UCEC	ICGC	LGVFNE	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.0556
p.R195C	SIDM00948	Burkitt's Lymphoma	GDSC	LGVFNE	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.0556
p.R195C	DG-75	haematopoietic and lymphoid tissue	COSMIC	LGVFNE	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.0556
p.R195L	TCGA-64-1679	LUAD	TCGA	LGVFNE	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.0556
p.R195L	DO26200	LUAD	ICGC	LGVFNE	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.0556
p.N209K	TCGA-AB-2834	LAML	TCGA	LGVFNE	LIG_APCC_ABBA_1	205:210	Mutation altering degron motif	0.5806
p.N209K	DO21749	LAML	ICGC	LGVFNE	LIG_APCC_ABBA_1	205:210	Mutation altering degron motif	0.5806
p.E203K	TCGA-C8-A26Y	BRCA	TCGA	LGVFNE	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.2778
p.E203K	DO1273	BRCA	ICGC	LGVFNE	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.2778
p.P742L	TCGA-EE-A3JD	SKCM	TCGA	SDDDVPSV	DEG_COP1_1	751:758	Mutation rewiring degron network	0.0833
p.P742L	DO50299	SKCM	ICGC	SDDDVPSV	DEG_COP1_1	751:758	Mutation rewiring degron network	0.0833
p.G762R	TCGA-FD-A6TC	BLCA	TCGA	SDDDVPSV	DEG_COP1_1	751:758	Mutation rewiring degron network	0.2222
p.G762R	DO49755	BLCA	ICGC	SDDDVPSV	DEG_COP1_1	751:758	Mutation rewiring degron network	0.2222
p.E203Q	TCGA-GC-A3WC	BLCA	TCGA	LGVFNE	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.2778
p.E203Q	DO755	BLCA	ICGC	LGVFNE	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.2778
p.C741S	TCGA-UB-AA0U	LIHC	TCGA	SDDDVPSV	DEG_COP1_1	751:758	Mutation rewiring degron network	0.0556
p.C741S	DO52323	LIHC	ICGC	SDDDVPSV	DEG_COP1_1	751:758	Mutation rewiring degron network	0.0556
p.T211P	TCGA-VQ-A91X	STAD	TCGA	LGVFNE	LIG_APCC_ABBA_1	205:210	Mutation blocking phosphorylation signal	0.75
p.T211P	DO51790	STAD	ICGC	LGVFNE	LIG_APCC_ABBA_1	205:210	Mutation blocking phosphorylation signal	0.75
p.D753G	DO234366	ESAD	ICGC	SDDDVPSV	DEG_COP1_1	751:758	Mutation altering degron motif	0.6087
p.D204E	DO229041	LICA	ICGC	LGVFNE	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.3056
p.L202I	DO229045	LICA	ICGC	LGVFNE	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.25
p.L744Q	DO50922	LICA	ICGC	SDDDVPSV	DEG_COP1_1	751:758	Mutation rewiring degron network	0.1389
p.S768F	DO222662	MELA	ICGC	SDDDVPSV	DEG_COP1_1	751:758	Mutation rewiring degron network	0.0556
p.D754Y	DO50657	ORCA	ICGC	SDDDVPSV	DEG_COP1_1	751:758	Mutation altering degron motif	0.6214
p.V207M	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	LGVFNE	LIG_APCC_ABBA_1	205:210	Mutation altering degron motif	0.6097
p.V207M	ACH-000917	Esophageal Cancer	CCLE	LGVFNE	LIG_APCC_ABBA_1	205:210	Mutation altering degron motif	0.6097
p.V207M	TE-4	oesophagus	COSMIC	LGVFNE	LIG_APCC_ABBA_1	205:210	Mutation altering degron motif	0.6097
p.R198Q	SIDM00929	Chondrosarcoma	GDSC	LGVFNE	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.1389
p.R198Q	CAL-78	bone	COSMIC	LGVFNE	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.1389

Kaplan plot for ATAD2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATAD2

UniProt ID: Q6PL18

Entrez ID: 29028

Protein name: ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ATAD2 in