DegronMD

Uniprot ID: Q6PL18

Source protein: ATPase family AAA domain-containing protein 2

Source gene: ATAD2

Class: DEG_COP1_1

Location: 751:758

E3 ligase: COP1

DEGRON score: 0.9949

ASA_SCORE: 69.4125

COIL: 0.8131

CONS_SCORE: 0.1355

DSS_SCORE: 0.3914

HELIX: 0.1296

FCONS_SCORE: 0.6901

RIG_SCORE: 0.7498

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S767Y	TCGA-19-5956	GBM	TCGA	SDDDVPSV	DEG_COP1_1	0.0833
p.S767Y	DO13863	GBM	ICGC	SDDDVPSV	DEG_COP1_1	0.0833
p.P742L	TCGA-EE-A3JD	SKCM	TCGA	SDDDVPSV	DEG_COP1_1	0.0833
p.P742L	DO50299	SKCM	ICGC	SDDDVPSV	DEG_COP1_1	0.0833
p.G762R	TCGA-FD-A6TC	BLCA	TCGA	SDDDVPSV	DEG_COP1_1	0.2222
p.G762R	DO49755	BLCA	ICGC	SDDDVPSV	DEG_COP1_1	0.2222
p.C741S	TCGA-UB-AA0U	LIHC	TCGA	SDDDVPSV	DEG_COP1_1	0.0556
p.C741S	DO52323	LIHC	ICGC	SDDDVPSV	DEG_COP1_1	0.0556
p.D753G	DO234366	ESAD	ICGC	SDDDVPSV	DEG_COP1_1	0.6087
p.L744Q	DO50922	LICA	ICGC	SDDDVPSV	DEG_COP1_1	0.1389
p.S768F	DO222662	MELA	ICGC	SDDDVPSV	DEG_COP1_1	0.0556
p.D754Y	DO50657	ORCA	ICGC	SDDDVPSV	DEG_COP1_1	0.6214

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PL18	ATPase family AAA domain-containing protein 2	DEG_COP1_1	751:758	SDDDVPSV	COP1	0.9949	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons