DegronMD

Uniprot ID: Q8N9V6

Source protein: Ankyrin repeat domain-containing protein 53

Source gene: ANKRD53

Class: LIG_APCC_ABBA_1

Location: 408:413

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9292

ASA_SCORE: 75.2833

COIL: 0.8653

CONS_SCORE: 0.4214

DSS_SCORE: 0.6825

HELIX: 0.0103

FCONS_SCORE: 0.912

RIG_SCORE: 0.6146

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q404R	TCGA-A6-6781	COAD	TCGA	LGVHPD	LIG_APCC_ABBA_1	0.2222
p.R401Q	DO10582	COAD	ICGC	LGVHPD	LIG_APCC_ABBA_1	0.1389
p.A411V	DO222305	DLBC	ICGC	LGVHPD	LIG_APCC_ABBA_1	0.6936
p.G399V	DO229022	LICA	ICGC	LGVHPD	LIG_APCC_ABBA_1	0.0833
p.G399C	DO229031	LICA	ICGC	LGVHPD	LIG_APCC_ABBA_1	0.0833
p.V413L	DO229034	LICA	ICGC	LGVHPD	LIG_APCC_ABBA_1	0.6765
p.R423L	DO229037	LICA	ICGC	LGVHPD	LIG_APCC_ABBA_1	0.0556
p.H403Y	DO223921	LIHC	ICGC	LGVHPD	LIG_APCC_ABBA_1	0.1944
p.P417A	DO28823	OV	ICGC	LGVHPD	LIG_APCC_ABBA_1	0.2222
p.R415Q	DO41020	UCEC	ICGC	LGVHPD	LIG_APCC_ABBA_1	0.2778
p.R423C	DO42280	UCEC	ICGC	LGVHPD	LIG_APCC_ABBA_1	0.0556
p.R415W	DO223286	UCEC	ICGC	LGVHPD	LIG_APCC_ABBA_1	0.2778
p.R415W	IA-LM	lung	COSMIC	LGVHPD	LIG_APCC_ABBA_1	0.2778
p.R415W	KP-N-RT-BM-1	autonomic_ganglia	COSMIC	LGVHPD	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N9V6	Ankyrin repeat domain-containing protein 53	LIG_APCC_ABBA_1	408:413	LGVHPD	APC,CDC20,FZR1	0.9292	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons