DegronMD - Q8N9V6(ANKRD53)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q404R	TCGA-A6-6781	COAD	TCGA	LGVHPD	LIG_APCC_ABBA_1	408:413	Mutation rewiring degron network	0.2222
p.Q404R	TCGA-A6-6781	COAD	TCGA	RLGVHPD	LIG_APCC_ABBAyCdc20_2	407:413	Mutation rewiring degron network	0.25
p.R401Q	DO10582	COAD	ICGC	LGVHPD	LIG_APCC_ABBA_1	408:413	Mutation rewiring degron network	0.1389
p.R401Q	DO10582	COAD	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	407:413	Mutation rewiring degron network	0.1667
p.H397L	DO230334	COCA	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	407:413	Mutation rewiring degron network	0.0556
p.H397L	DO229010	COCA	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	407:413	Mutation rewiring degron network	0.0556
p.H397L	DO229013	COCA	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	407:413	Mutation rewiring degron network	0.0556
p.H397L	DO229016	COCA	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	407:413	Mutation rewiring degron network	0.0556
p.H397L	DO228947	LICA	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	407:413	Mutation rewiring degron network	0.0556
p.H397L	DO229047	LICA	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	407:413	Mutation rewiring degron network	0.0556
p.H397L	DO230535	LUSC	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	407:413	Mutation rewiring degron network	0.0556
p.H397L	DO231072	LUSC	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	407:413	Mutation rewiring degron network	0.0556
p.A411V	DO222305	DLBC	ICGC	LGVHPD	LIG_APCC_ABBA_1	408:413	Mutation altering degron motif	0.6936
p.A411V	DO222305	DLBC	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	407:413	Mutation altering degron motif	0.6936
p.G399V	DO229022	LICA	ICGC	LGVHPD	LIG_APCC_ABBA_1	408:413	Mutation rewiring degron network	0.0833
p.G399V	DO229022	LICA	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	407:413	Mutation rewiring degron network	0.1111
p.G399C	DO229031	LICA	ICGC	LGVHPD	LIG_APCC_ABBA_1	408:413	Mutation rewiring degron network	0.0833
p.G399C	DO229031	LICA	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	407:413	Mutation rewiring degron network	0.1111
p.V413L	DO229034	LICA	ICGC	LGVHPD	LIG_APCC_ABBA_1	408:413	Mutation altering degron motif	0.6765
p.V413L	DO229034	LICA	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	407:413	Mutation altering degron motif	0.6765
p.R423L	DO229037	LICA	ICGC	LGVHPD	LIG_APCC_ABBA_1	408:413	Mutation rewiring degron network	0.0556
p.R423L	DO229037	LICA	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	407:413	Mutation rewiring degron network	0.0556
p.H403Y	DO223921	LIHC	ICGC	LGVHPD	LIG_APCC_ABBA_1	408:413	Mutation rewiring degron network	0.1944
p.H403Y	DO223921	LIHC	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	407:413	Mutation rewiring degron network	0.2222
p.P417A	DO28823	OV	ICGC	LGVHPD	LIG_APCC_ABBA_1	408:413	Mutation rewiring degron network	0.2222
p.P417A	DO28823	OV	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	407:413	Mutation rewiring degron network	0.2222
p.R415Q	DO41020	UCEC	ICGC	LGVHPD	LIG_APCC_ABBA_1	408:413	Mutation rewiring degron network	0.2778
p.R415Q	DO41020	UCEC	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	407:413	Mutation rewiring degron network	0.2778
p.R423C	DO42280	UCEC	ICGC	LGVHPD	LIG_APCC_ABBA_1	408:413	Mutation rewiring degron network	0.0556
p.R423C	DO42280	UCEC	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	407:413	Mutation rewiring degron network	0.0556
p.R415W	DO223286	UCEC	ICGC	LGVHPD	LIG_APCC_ABBA_1	408:413	Mutation rewiring degron network	0.2778
p.R415W	DO223286	UCEC	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	407:413	Mutation rewiring degron network	0.2778
p.R415W	IA-LM	lung	COSMIC	LGVHPD	LIG_APCC_ABBA_1	408:413	Mutation rewiring degron network	0.2778
p.R415W	IA-LM	lung	COSMIC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	407:413	Mutation rewiring degron network	0.2778
p.R415W	KP-N-RT-BM-1	autonomic ganglia	COSMIC	LGVHPD	LIG_APCC_ABBA_1	408:413	Mutation rewiring degron network	0.2778
p.R415W	KP-N-RT-BM-1	autonomic ganglia	COSMIC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	407:413	Mutation rewiring degron network	0.2778

Kaplan plot for ANKRD53 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANKRD53

UniProt ID: Q8N9V6

Entrez ID: 79998

Protein name: Ankyrin repeat domain-containing protein 53

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ANKRD53 in