DegronMD

Uniprot ID: Q8N9V6

Source protein: Ankyrin repeat domain-containing protein 53

Source gene: ANKRD53

Class: LIG_APCC_ABBAyCdc20_2

Location: 407:413

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.943

ASA_SCORE: 78.9

COIL: 0.8069

CONS_SCORE: 0.4312

DSS_SCORE: 0.6883

HELIX: 0.0111

FCONS_SCORE: 0.9214

RIG_SCORE: 0.6156

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q404R	TCGA-A6-6781	COAD	TCGA	RLGVHPD	LIG_APCC_ABBAyCdc20_2	0.25
p.R401Q	DO10582	COAD	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.H397L	DO230334	COCA	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	0.0556
p.H397L	DO229010	COCA	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	0.0556
p.H397L	DO229013	COCA	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	0.0556
p.H397L	DO229016	COCA	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	0.0556
p.H397L	DO228947	LICA	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	0.0556
p.H397L	DO229047	LICA	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	0.0556
p.H397L	DO230535	LUSC	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	0.0556
p.H397L	DO231072	LUSC	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	0.0556
p.A411V	DO222305	DLBC	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	0.6936
p.G399V	DO229022	LICA	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	0.1111
p.G399C	DO229031	LICA	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	0.1111
p.V413L	DO229034	LICA	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	0.6765
p.R423L	DO229037	LICA	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	0.0556
p.H403Y	DO223921	LIHC	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	0.2222
p.P417A	DO28823	OV	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R415Q	DO41020	UCEC	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.R423C	DO42280	UCEC	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R415W	DO223286	UCEC	ICGC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.R415W	IA-LM	lung	COSMIC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.R415W	KP-N-RT-BM-1	autonomic_ganglia	COSMIC	RLGVHPD	LIG_APCC_ABBAyCdc20_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N9V6	Ankyrin repeat domain-containing protein 53	LIG_APCC_ABBAyCdc20_2	407:413	RLGVHPD	APC,CDC20,FZR1	0.943	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons