DegronMD

Uniprot ID: Q6DT37

Source protein: Serine/threonine-protein kinase MRCK gamma

Source gene: CDC42BPG

Class: LIG_APCC_ABBA_1

Location: 938:943

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9827

ASA_SCORE: 69.35

COIL: 0.8303

CONS_SCORE: 0.3705

DSS_SCORE: 0.4614

HELIX: 0.0772

FCONS_SCORE: 1.1175

RIG_SCORE: 0.7089

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G952D	TCGA-OD-A75X	SKCM	TCGA	LGVHPE	LIG_APCC_ABBA_1	0.0833
p.G952D	DO48601	SKCM	ICGC	LGVHPE	LIG_APCC_ABBA_1	0.0833
p.R935C	DO228589	LICA	ICGC	LGVHPE	LIG_APCC_ABBA_1	0.25
p.R935C	DO220878	MELA	ICGC	LGVHPE	LIG_APCC_ABBA_1	0.25
p.P942H	DO228976	LICA	ICGC	LGVHPE	LIG_APCC_ABBA_1	0.6583
p.T936K	DO229018	LICA	ICGC	LGVHPE	LIG_APCC_ABBA_1	0.2778
p.P930T	DO229029	LICA	ICGC	LGVHPE	LIG_APCC_ABBA_1	0.1111
p.P942S	DO232519	PBCA	ICGC	LGVHPE	LIG_APCC_ABBA_1	0.5641
p.P928R	SIDM01409	Bladder Carcinoma	GDSC	LGVHPE	LIG_APCC_ABBA_1	0.0556
p.R935H	ACH-000322	Skin Cancer	CCLE	LGVHPE	LIG_APCC_ABBA_1	0.25
p.R935H	ACH-002460	Skin Cancer	CCLE	LGVHPE	LIG_APCC_ABBA_1	0.25
p.T936I	ACH-000995	Leukemia	CCLE	LGVHPE	LIG_APCC_ABBA_1	0.2778
p.F953L	ACH-001407	Bladder Cancer	CCLE	LGVHPE	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6DT37	Serine/threonine-protein kinase MRCK gamma	LIG_APCC_ABBA_1	938:943	LGVHPE	APC,CDC20,FZR1	0.9827	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons