DegronMD - Q6DT37(CDC42BPG)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R496L	TCGA-85-8664	LUSC	TCGA	LRQELDRLH	DEG_APCC_DBOX_1	487:495	Mutation rewiring degron network	0.3056
p.R496L	DO45469	LUSC	ICGC	LRQELDRLH	DEG_APCC_DBOX_1	487:495	Mutation rewiring degron network	0.3056
p.D484E	TCGA-A5-A1OH	UCEC	TCGA	LRQELDRLH	DEG_APCC_DBOX_1	487:495	Mutation rewiring degron network	0.25
p.D484E	DO48180	UCEC	ICGC	LRQELDRLH	DEG_APCC_DBOX_1	487:495	Mutation rewiring degron network	0.25
p.G952D	TCGA-OD-A75X	SKCM	TCGA	LGVHPE	LIG_APCC_ABBA_1	938:943	Mutation rewiring degron network	0.0833
p.G952D	DO48601	SKCM	ICGC	LGVHPE	LIG_APCC_ABBA_1	938:943	Mutation rewiring degron network	0.0833
p.P481L	TCGA-W3-AA1V	SKCM	TCGA	LRQELDRLH	DEG_APCC_DBOX_1	487:495	Mutation rewiring degron network	0.1667
p.P481L	DO51276	SKCM	ICGC	LRQELDRLH	DEG_APCC_DBOX_1	487:495	Mutation rewiring degron network	0.1667
p.R488W	DO222765	COCA	ICGC	LRQELDRLH	DEG_APCC_DBOX_1	487:495	Mutation altering degron motif	0.8634
p.R502W	DO52481	COCA	ICGC	LRQELDRLH	DEG_APCC_DBOX_1	487:495	Mutation rewiring degron network	0.1389
p.R935C	DO228589	LICA	ICGC	LGVHPE	LIG_APCC_ABBA_1	938:943	Mutation rewiring degron network	0.25
p.R935C	DO220878	MELA	ICGC	LGVHPE	LIG_APCC_ABBA_1	938:943	Mutation rewiring degron network	0.25
p.P942H	DO228976	LICA	ICGC	LGVHPE	LIG_APCC_ABBA_1	938:943	Mutation altering degron motif	0.6583
p.T936K	DO229018	LICA	ICGC	LGVHPE	LIG_APCC_ABBA_1	938:943	Mutation rewiring degron network	0.2778
p.P930T	DO229029	LICA	ICGC	LGVHPE	LIG_APCC_ABBA_1	938:943	Mutation rewiring degron network	0.1111
p.P477Q	DO229041	LICA	ICGC	LRQELDRLH	DEG_APCC_DBOX_1	487:495	Mutation rewiring degron network	0.0556
p.R488Q	DO35442	PACA	ICGC	LRQELDRLH	DEG_APCC_DBOX_1	487:495	Mutation altering degron motif	0.7329
p.P942S	DO232519	PBCA	ICGC	LGVHPE	LIG_APCC_ABBA_1	938:943	Mutation altering degron motif	0.5641
p.R496W	SIDM02039	Colorectal Carcinoma	GDSC	LRQELDRLH	DEG_APCC_DBOX_1	487:495	Mutation rewiring degron network	0.3056
p.R496Q	SIDM00935	Other Solid Cancers	GDSC	LRQELDRLH	DEG_APCC_DBOX_1	487:495	Mutation rewiring degron network	0.3056
p.P928R	SIDM01409	Bladder Carcinoma	GDSC	LGVHPE	LIG_APCC_ABBA_1	938:943	Mutation rewiring degron network	0.0556
p.R935H	ACH-000322	Skin Cancer	CCLE	LGVHPE	LIG_APCC_ABBA_1	938:943	Mutation rewiring degron network	0.25
p.R935H	ACH-002460	Skin Cancer	CCLE	LGVHPE	LIG_APCC_ABBA_1	938:943	Mutation rewiring degron network	0.25
p.T936I	ACH-000995	Leukemia	CCLE	LGVHPE	LIG_APCC_ABBA_1	938:943	Mutation rewiring degron network	0.2778
p.F953L	ACH-001407	Bladder Cancer	CCLE	LGVHPE	LIG_APCC_ABBA_1	938:943	Mutation rewiring degron network	0.0556

Kaplan plot for CDC42BPG in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDC42BPG

UniProt ID: Q6DT37

Entrez ID: 55561

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDC42BPG in