DegronMD

Uniprot ID: Q6DT37

Source protein: Serine/threonine-protein kinase MRCK gamma

Source gene: CDC42BPG

Class: DEG_APCC_DBOX_1

Location: 487:495

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8228

ASA_SCORE: 96.1222

COIL: 0.039

CONS_SCORE: 0.3732

DSS_SCORE: 0.6734

HELIX: 0.9616

FCONS_SCORE: 1.1414

RIG_SCORE: 0.722

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R496L	TCGA-85-8664	LUSC	TCGA	LRQELDRLH	DEG_APCC_DBOX_1	0.3056
p.R496L	DO45469	LUSC	ICGC	LRQELDRLH	DEG_APCC_DBOX_1	0.3056
p.D484E	TCGA-A5-A1OH	UCEC	TCGA	LRQELDRLH	DEG_APCC_DBOX_1	0.25
p.D484E	DO48180	UCEC	ICGC	LRQELDRLH	DEG_APCC_DBOX_1	0.25
p.P481L	TCGA-W3-AA1V	SKCM	TCGA	LRQELDRLH	DEG_APCC_DBOX_1	0.1667
p.P481L	DO51276	SKCM	ICGC	LRQELDRLH	DEG_APCC_DBOX_1	0.1667
p.R488W	DO222765	COCA	ICGC	LRQELDRLH	DEG_APCC_DBOX_1	0.8634
p.R502W	DO52481	COCA	ICGC	LRQELDRLH	DEG_APCC_DBOX_1	0.1389
p.P477Q	DO229041	LICA	ICGC	LRQELDRLH	DEG_APCC_DBOX_1	0.0556
p.R488Q	DO35442	PACA	ICGC	LRQELDRLH	DEG_APCC_DBOX_1	0.7329
p.R496W	SIDM02039	Colorectal Carcinoma	GDSC	LRQELDRLH	DEG_APCC_DBOX_1	0.3056
p.R496Q	SIDM00935	Other Solid Cancers	GDSC	LRQELDRLH	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6DT37	Serine/threonine-protein kinase MRCK gamma	DEG_APCC_DBOX_1	487:495	LRQELDRLH	APC,CDC20,FZR1	0.8228	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons