DegronMD

Uniprot ID: Q5T160

Source protein: Probable arginine--tRNA ligase, mitochondrial

Source gene: RARS2

Class: LIG_APCC_ABBA_1

Location: 259:264

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.678

ASA_SCORE: 47.7167

COIL: 0.692

CONS_SCORE: 0.5982

DSS_SCORE: 0.0251

HELIX: 0.1127

FCONS_SCORE: 1.2673

RIG_SCORE: 0.8822

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R258H	TCGA-A5-A0VP	UCEC	TCGA	LGVYFD	LIG_APCC_ABBA_1	0.3056
p.R258H	TCGA-NH-A5IV	COAD	TCGA	LGVYFD	LIG_APCC_ABBA_1	0.3056
p.R258H	DO49095	COAD	ICGC	LGVYFD	LIG_APCC_ABBA_1	0.3056
p.R258H	DO42600	UCEC	ICGC	LGVYFD	LIG_APCC_ABBA_1	0.3056
p.S270T	TCGA-EI-6882	READ	TCGA	LGVYFD	LIG_APCC_ABBA_1	0.1667
p.S270T	DO36531	READ	ICGC	LGVYFD	LIG_APCC_ABBA_1	0.1667
p.R273H	TCGA-EO-A22R	UCEC	TCGA	LGVYFD	LIG_APCC_ABBA_1	0.0833
p.R273H	DO42713	UCEC	ICGC	LGVYFD	LIG_APCC_ABBA_1	0.0833
p.G260R	SIDM02072	Colorectal Carcinoma	GDSC	LGVYFD	LIG_APCC_ABBA_1	0.6457
p.R254W	SIDM00118	Colorectal Carcinoma	GDSC	LGVYFD	LIG_APCC_ABBA_1	0.1944
p.R254W	ACH-001081	Colon/Colorectal Cancer	CCLE	LGVYFD	LIG_APCC_ABBA_1	0.1944
p.R254W	HCC2998	large_intestine	COSMIC	LGVYFD	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T160	Probable arginine--tRNA ligase, mitochondrial	LIG_APCC_ABBA_1	259:264	LGVYFD	APC,CDC20,FZR1	0.678	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons