DegronMD

Uniprot ID: Q6ZVD7

Source protein: Storkhead-box protein 1

Source gene: STOX1

Class: DEG_SCF_FBW7_1

Location: 805:812

E3 ligase: FBXW7

DEGRON score: 0.9411

ASA_SCORE: 80.7875

COIL: 0.8838

CONS_SCORE: 0.2711

DSS_SCORE: 0.5922

HELIX: 0.0345

FCONS_SCORE: 0.9879

RIG_SCORE: 0.6516

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R796I	TCGA-AA-3984	COAD	TCGA	LHATPGES	DEG_SCF_FBW7_1	0.0833
p.R796I	TCGA-AP-A056	UCEC	TCGA	LHATPGES	DEG_SCF_FBW7_1	0.0833
p.R796I	TCGA-AX-A05Z	UCEC	TCGA	LHATPGES	DEG_SCF_FBW7_1	0.0833
p.R796I	TCGA-EI-6917	READ	TCGA	LHATPGES	DEG_SCF_FBW7_1	0.0833
p.R796I	DO222830	BTCA	ICGC	LHATPGES	DEG_SCF_FBW7_1	0.0833
p.R796I	DO9002	COAD	ICGC	LHATPGES	DEG_SCF_FBW7_1	0.0833
p.R796I	DO36881	READ	ICGC	LHATPGES	DEG_SCF_FBW7_1	0.0833
p.R796I	DO40884	UCEC	ICGC	LHATPGES	DEG_SCF_FBW7_1	0.0833
p.R796I	DO43971	UCEC	ICGC	LHATPGES	DEG_SCF_FBW7_1	0.0833
p.C799Y	TCGA-AP-A1DK	UCEC	TCGA	LHATPGES	DEG_SCF_FBW7_1	0.1667
p.E820K	TCGA-CN-4723	HNSC	TCGA	LHATPGES	DEG_SCF_FBW7_1	0.1111
p.E820K	DO14830	HNSC	ICGC	LHATPGES	DEG_SCF_FBW7_1	0.1111
p.R796T	TCGA-K4-A83P	BLCA	TCGA	LHATPGES	DEG_SCF_FBW7_1	0.0833
p.R796T	DO49787	BLCA	ICGC	LHATPGES	DEG_SCF_FBW7_1	0.0833
p.R796G	TCGA-VP-A87E	PRAD	TCGA	LHATPGES	DEG_SCF_FBW7_1	0.0833
p.R796G	DO51387	PRAD	ICGC	LHATPGES	DEG_SCF_FBW7_1	0.0833
p.P815S	DO233652	GACA	ICGC	LHATPGES	DEG_SCF_FBW7_1	0.25
p.P815S	DO50681	ORCA	ICGC	LHATPGES	DEG_SCF_FBW7_1	0.25
p.L817I	DO221117	MALY	ICGC	LHATPGES	DEG_SCF_FBW7_1	0.1944
p.L817I	ACH-001377	Pancreatic Cancer	CCLE	LHATPGES	DEG_SCF_FBW7_1	0.1944
p.P800Q	DO28923	OV	ICGC	LHATPGES	DEG_SCF_FBW7_1	0.1944
p.L813F	DO37961	SKCM	ICGC	LHATPGES	DEG_SCF_FBW7_1	0.3056
p.S819N	CAL-54	kidney	COSMIC	LHATPGES	DEG_SCF_FBW7_1	0.1389
p.Q795R	NCI-H1573	lung	COSMIC	LHATPGES	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZVD7	Storkhead-box protein 1	DEG_SCF_FBW7_1	805:812	LHATPGES	FBXW7	0.9411	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons