DegronMD

Uniprot ID: A1L4K1

Source protein: Fibronectin type III and SPRY domain-containing protein 2

Source gene: FSD2

Class: LIG_APCC_ABBA_1

Location: 33:38

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9973

ASA_SCORE: 77.3667

COIL: 0.7087

CONS_SCORE: 0.3752

DSS_SCORE: 0.4081

HELIX: 0.2277

FCONS_SCORE: 1.082

RIG_SCORE: 0.7893

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D25E	TCGA-60-2714	LUSC	TCGA	LHLFPE	LIG_APCC_ABBA_1	0.1111
p.D25E	DO26530	LUSC	ICGC	LHLFPE	LIG_APCC_ABBA_1	0.1111
p.V47I	TCGA-90-A4ED	LUSC	TCGA	LHLFPE	LIG_APCC_ABBA_1	0.0833
p.V47I	DO45482	LUSC	ICGC	LHLFPE	LIG_APCC_ABBA_1	0.0833
p.E30K	TCGA-A6-2686	COAD	TCGA	LHLFPE	LIG_APCC_ABBA_1	0.25
p.E30K	TCGA-VS-A8QC	CESC	TCGA	LHLFPE	LIG_APCC_ABBA_1	0.25
p.E30K	DO51628	CESC	ICGC	LHLFPE	LIG_APCC_ABBA_1	0.25
p.E30K	DO7828	COAD	ICGC	LHLFPE	LIG_APCC_ABBA_1	0.25
p.M43I	TCGA-CN-5369	HNSC	TCGA	LHLFPE	LIG_APCC_ABBA_1	0.1944
p.M43I	DO16069	HNSC	ICGC	LHLFPE	LIG_APCC_ABBA_1	0.1944
p.H34N	SIDM01020	Plasma Cell Myeloma	GDSC	LHLFPE	LIG_APCC_ABBA_1	0.6312
p.H34N	ACH-000380	Myeloma	CCLE	LHLFPE	LIG_APCC_ABBA_1	0.6312
p.H34N	KMS-12-BM	haematopoietic_and_lymphoid_tissue	COSMIC	LHLFPE	LIG_APCC_ABBA_1	0.6312
p.D31A	SIDM00217	Colorectal Carcinoma	GDSC	LHLFPE	LIG_APCC_ABBA_1	0.2778
p.D31A	ACH-000999	Colon/Colorectal Cancer	CCLE	LHLFPE	LIG_APCC_ABBA_1	0.2778
p.D31A	SNU-1040	large_intestine	COSMIC	LHLFPE	LIG_APCC_ABBA_1	0.2778
p.M43L	SIDM01372	Pancreatic Carcinoma	GDSC	LHLFPE	LIG_APCC_ABBA_1	0.1944
p.M43L	ACH-000266	Pancreatic Cancer	CCLE	LHLFPE	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1L4K1	Fibronectin type III and SPRY domain-containing protein 2	LIG_APCC_ABBA_1	33:38	LHLFPE	APC,CDC20,FZR1	0.9973	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons