DegronMD - A1L4K1(FSD2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D25E	TCGA-60-2714	LUSC	TCGA	LHLFPE	LIG_APCC_ABBA_1	33:38	Mutation rewiring degron network	0.1111
p.D25E	TCGA-60-2714	LUSC	TCGA	RLHLFPE	LIG_APCC_ABBAyCdc20_2	32:38	Mutation rewiring degron network	0.1389
p.D25E	DO26530	LUSC	ICGC	LHLFPE	LIG_APCC_ABBA_1	33:38	Mutation rewiring degron network	0.1111
p.D25E	DO26530	LUSC	ICGC	RLHLFPE	LIG_APCC_ABBAyCdc20_2	32:38	Mutation rewiring degron network	0.1389
p.V47I	TCGA-90-A4ED	LUSC	TCGA	LHLFPE	LIG_APCC_ABBA_1	33:38	Mutation rewiring degron network	0.0833
p.V47I	TCGA-90-A4ED	LUSC	TCGA	RLHLFPE	LIG_APCC_ABBAyCdc20_2	32:38	Mutation rewiring degron network	0.0833
p.V47I	DO45482	LUSC	ICGC	LHLFPE	LIG_APCC_ABBA_1	33:38	Mutation rewiring degron network	0.0833
p.V47I	DO45482	LUSC	ICGC	RLHLFPE	LIG_APCC_ABBAyCdc20_2	32:38	Mutation rewiring degron network	0.0833
p.E30K	TCGA-A6-2686	COAD	TCGA	LHLFPE	LIG_APCC_ABBA_1	33:38	Mutation rewiring degron network	0.25
p.E30K	TCGA-A6-2686	COAD	TCGA	RLHLFPE	LIG_APCC_ABBAyCdc20_2	32:38	Mutation rewiring degron network	0.2778
p.E30K	TCGA-VS-A8QC	CESC	TCGA	LHLFPE	LIG_APCC_ABBA_1	33:38	Mutation rewiring degron network	0.25
p.E30K	TCGA-VS-A8QC	CESC	TCGA	RLHLFPE	LIG_APCC_ABBAyCdc20_2	32:38	Mutation rewiring degron network	0.2778
p.E30K	DO51628	CESC	ICGC	LHLFPE	LIG_APCC_ABBA_1	33:38	Mutation rewiring degron network	0.25
p.E30K	DO51628	CESC	ICGC	RLHLFPE	LIG_APCC_ABBAyCdc20_2	32:38	Mutation rewiring degron network	0.2778
p.E30K	DO7828	COAD	ICGC	LHLFPE	LIG_APCC_ABBA_1	33:38	Mutation rewiring degron network	0.25
p.E30K	DO7828	COAD	ICGC	RLHLFPE	LIG_APCC_ABBAyCdc20_2	32:38	Mutation rewiring degron network	0.2778
p.R32K	TCGA-AA-3984	COAD	TCGA	RLHLFPE	LIG_APCC_ABBAyCdc20_2	32:38	Mutation altering degron motif	0.6126
p.R32K	DO9002	COAD	ICGC	RLHLFPE	LIG_APCC_ABBAyCdc20_2	32:38	Mutation altering degron motif	0.6126
p.M43I	TCGA-CN-5369	HNSC	TCGA	LHLFPE	LIG_APCC_ABBA_1	33:38	Mutation rewiring degron network	0.1944
p.M43I	TCGA-CN-5369	HNSC	TCGA	RLHLFPE	LIG_APCC_ABBAyCdc20_2	32:38	Mutation rewiring degron network	0.1944
p.M43I	DO16069	HNSC	ICGC	LHLFPE	LIG_APCC_ABBA_1	33:38	Mutation rewiring degron network	0.1944
p.M43I	DO16069	HNSC	ICGC	RLHLFPE	LIG_APCC_ABBAyCdc20_2	32:38	Mutation rewiring degron network	0.1944
p.H34N	SIDM01020	Plasma Cell Myeloma	GDSC	LHLFPE	LIG_APCC_ABBA_1	33:38	Mutation altering degron motif	0.6312
p.H34N	SIDM01020	Plasma Cell Myeloma	GDSC	RLHLFPE	LIG_APCC_ABBAyCdc20_2	32:38	Mutation altering degron motif	0.6312
p.H34N	ACH-000380	Myeloma	CCLE	LHLFPE	LIG_APCC_ABBA_1	33:38	Mutation altering degron motif	0.6312
p.H34N	ACH-000380	Myeloma	CCLE	RLHLFPE	LIG_APCC_ABBAyCdc20_2	32:38	Mutation altering degron motif	0.6312
p.H34N	KMS-12-BM	haematopoietic and lymphoid tissue	COSMIC	LHLFPE	LIG_APCC_ABBA_1	33:38	Mutation altering degron motif	0.6312
p.H34N	KMS-12-BM	haematopoietic and lymphoid tissue	COSMIC	RLHLFPE	LIG_APCC_ABBAyCdc20_2	32:38	Mutation altering degron motif	0.6312
p.D31A	SIDM00217	Colorectal Carcinoma	GDSC	LHLFPE	LIG_APCC_ABBA_1	33:38	Mutation rewiring degron network	0.2778
p.D31A	SIDM00217	Colorectal Carcinoma	GDSC	RLHLFPE	LIG_APCC_ABBAyCdc20_2	32:38	Mutation rewiring degron network	0.3056
p.D31A	ACH-000999	Colon/Colorectal Cancer	CCLE	LHLFPE	LIG_APCC_ABBA_1	33:38	Mutation rewiring degron network	0.2778
p.D31A	ACH-000999	Colon/Colorectal Cancer	CCLE	RLHLFPE	LIG_APCC_ABBAyCdc20_2	32:38	Mutation rewiring degron network	0.3056
p.D31A	SNU-1040	large intestine	COSMIC	LHLFPE	LIG_APCC_ABBA_1	33:38	Mutation rewiring degron network	0.2778
p.D31A	SNU-1040	large intestine	COSMIC	RLHLFPE	LIG_APCC_ABBAyCdc20_2	32:38	Mutation rewiring degron network	0.3056
p.M43L	SIDM01372	Pancreatic Carcinoma	GDSC	LHLFPE	LIG_APCC_ABBA_1	33:38	Mutation rewiring degron network	0.1944
p.M43L	SIDM01372	Pancreatic Carcinoma	GDSC	RLHLFPE	LIG_APCC_ABBAyCdc20_2	32:38	Mutation rewiring degron network	0.1944
p.M43L	ACH-000266	Pancreatic Cancer	CCLE	LHLFPE	LIG_APCC_ABBA_1	33:38	Mutation rewiring degron network	0.1944
p.M43L	ACH-000266	Pancreatic Cancer	CCLE	RLHLFPE	LIG_APCC_ABBAyCdc20_2	32:38	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FSD2

UniProt ID: A1L4K1

Entrez ID: 123722

Protein name: Fibronectin type III and SPRY domain-containing protein 2 (SPRY domain-containing protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FSD2 in