DegronMD

Uniprot ID: A1L4K1

Source protein: Fibronectin type III and SPRY domain-containing protein 2

Source gene: FSD2

Class: LIG_APCC_ABBAyCdc20_2

Location: 32:38

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9765

ASA_SCORE: 82.8857

COIL: 0.6759

CONS_SCORE: 0.3784

DSS_SCORE: 0.4042

HELIX: 0.2591

FCONS_SCORE: 1.1076

RIG_SCORE: 0.7875

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D25E	TCGA-60-2714	LUSC	TCGA	RLHLFPE	LIG_APCC_ABBAyCdc20_2	0.1389
p.D25E	DO26530	LUSC	ICGC	RLHLFPE	LIG_APCC_ABBAyCdc20_2	0.1389
p.V47I	TCGA-90-A4ED	LUSC	TCGA	RLHLFPE	LIG_APCC_ABBAyCdc20_2	0.0833
p.V47I	DO45482	LUSC	ICGC	RLHLFPE	LIG_APCC_ABBAyCdc20_2	0.0833
p.E30K	TCGA-A6-2686	COAD	TCGA	RLHLFPE	LIG_APCC_ABBAyCdc20_2	0.2778
p.E30K	TCGA-VS-A8QC	CESC	TCGA	RLHLFPE	LIG_APCC_ABBAyCdc20_2	0.2778
p.E30K	DO51628	CESC	ICGC	RLHLFPE	LIG_APCC_ABBAyCdc20_2	0.2778
p.E30K	DO7828	COAD	ICGC	RLHLFPE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R32K	TCGA-AA-3984	COAD	TCGA	RLHLFPE	LIG_APCC_ABBAyCdc20_2	0.6126
p.R32K	DO9002	COAD	ICGC	RLHLFPE	LIG_APCC_ABBAyCdc20_2	0.6126
p.M43I	TCGA-CN-5369	HNSC	TCGA	RLHLFPE	LIG_APCC_ABBAyCdc20_2	0.1944
p.M43I	DO16069	HNSC	ICGC	RLHLFPE	LIG_APCC_ABBAyCdc20_2	0.1944
p.H34N	SIDM01020	Plasma Cell Myeloma	GDSC	RLHLFPE	LIG_APCC_ABBAyCdc20_2	0.6312
p.H34N	ACH-000380	Myeloma	CCLE	RLHLFPE	LIG_APCC_ABBAyCdc20_2	0.6312
p.H34N	KMS-12-BM	haematopoietic_and_lymphoid_tissue	COSMIC	RLHLFPE	LIG_APCC_ABBAyCdc20_2	0.6312
p.D31A	SIDM00217	Colorectal Carcinoma	GDSC	RLHLFPE	LIG_APCC_ABBAyCdc20_2	0.3056
p.D31A	ACH-000999	Colon/Colorectal Cancer	CCLE	RLHLFPE	LIG_APCC_ABBAyCdc20_2	0.3056
p.D31A	SNU-1040	large_intestine	COSMIC	RLHLFPE	LIG_APCC_ABBAyCdc20_2	0.3056
p.M43L	SIDM01372	Pancreatic Carcinoma	GDSC	RLHLFPE	LIG_APCC_ABBAyCdc20_2	0.1944
p.M43L	ACH-000266	Pancreatic Cancer	CCLE	RLHLFPE	LIG_APCC_ABBAyCdc20_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1L4K1	Fibronectin type III and SPRY domain-containing protein 2	LIG_APCC_ABBAyCdc20_2	32:38	RLHLFPE	APC,CDC20,FZR1	0.9765	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons