DegronMD

Uniprot ID: Q9NXV2

Source protein: BTB/POZ domain-containing protein KCTD5

Source gene: KCTD5

Class: DEG_SCF_FBW7_1

Location: 209:216

E3 ligase: FBXW7

DEGRON score: 0.9734

ASA_SCORE: 80.05

COIL: 0.8426

CONS_SCORE: 0.5035

DSS_SCORE: 0.4267

HELIX: 0.0403

FCONS_SCORE: 0.8802

RIG_SCORE: 0.7015

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V205M	TCGA-77-6845	LUSC	TCGA	LHNTPYGT	DEG_SCF_FBW7_1	0.2222
p.V204G	TCGA-B5-A11E	UCEC	TCGA	LHNTPYGT	DEG_SCF_FBW7_1	0.1944
p.L202P	DO6496	CLLE	ICGC	LHNTPYGT	DEG_SCF_FBW7_1	0.1389
p.E223Q	DO14252	HNSC	ICGC	LHNTPYGT	DEG_SCF_FBW7_1	0.5833
p.V217F	DO228976	LICA	ICGC	LHNTPYGT	DEG_SCF_FBW7_1	0.3056
p.G215V	DO229036	LICA	ICGC	LHNTPYGT	DEG_SCF_FBW7_1	0.6421
p.G215V	DO229035	LICA	ICGC	LHNTPYGT	DEG_SCF_FBW7_1	0.6421
p.R200K	DO47331	SKCM	ICGC	LHNTPYGT	DEG_SCF_FBW7_1	0.0833
p.E223D	DO222401	STAD	ICGC	LHNTPYGT	DEG_SCF_FBW7_1	0.5833
p.G215D	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	LHNTPYGT	DEG_SCF_FBW7_1	0.6087
p.G215D	ACH-002272	Lymphoma	CCLE	LHNTPYGT	DEG_SCF_FBW7_1	0.6087
p.G215D	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LHNTPYGT	DEG_SCF_FBW7_1	0.6087
p.A217V	SIDM00487	Colorectal Carcinoma	GDSC	LHNTPYGT	DEG_SCF_FBW7_1	0.3056
p.A217V	ACH-000963	Colon/Colorectal Cancer	CCLE	LHNTPYGT	DEG_SCF_FBW7_1	0.3056
p.A217V	CCK-81	large_intestine	COSMIC	LHNTPYGT	DEG_SCF_FBW7_1	0.3056
p.R205G	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	LHNTPYGT	DEG_SCF_FBW7_1	0.2222
p.P219L	HT-1080	soft_tissue	COSMIC	LHNTPYGT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NXV2	BTB/POZ domain-containing protein KCTD5	DEG_SCF_FBW7_1	209:216	LHNTPYGT	FBXW7	0.9734	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons