DegronMD - Q9NXV2(KCTD5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V205M	TCGA-77-6845	LUSC	TCGA	LHNTPYGT	DEG_SCF_FBW7_1	209:216	Mutation rewiring degron network	0.2222
p.V204G	TCGA-B5-A11E	UCEC	TCGA	LHNTPYGT	DEG_SCF_FBW7_1	209:216	Mutation rewiring degron network	0.1944
p.S232L	TCGA-EE-A2MF	SKCM	TCGA	LQERGSR	SCF_FBXL2	227:233	Mutation altering degron motif	0.6556
p.S232L	DO222491	MELA	ICGC	LQERGSR	SCF_FBXL2	227:233	Mutation altering degron motif	0.6556
p.S232L	DO51249	SKCM	ICGC	LQERGSR	SCF_FBXL2	227:233	Mutation altering degron motif	0.6556
p.G231S	TCGA-EE-A3J5	SKCM	TCGA	LQERGSR	SCF_FBXL2	227:233	Mutation altering degron motif	0.6993
p.L202P	DO6496	CLLE	ICGC	LHNTPYGT	DEG_SCF_FBW7_1	209:216	Mutation rewiring degron network	0.1389
p.E223Q	DO14252	HNSC	ICGC	LHNTPYGT	DEG_SCF_FBW7_1	209:216	Mutation blocking ubiquitination signal	0.5833
p.E223Q	DO14252	HNSC	ICGC	LQERGSR	SCF_FBXL2	227:233	Mutation blocking ubiquitination signal	0.6667
p.V217F	DO228976	LICA	ICGC	LHNTPYGT	DEG_SCF_FBW7_1	209:216	Mutation rewiring degron network	0.3056
p.V217F	DO228976	LICA	ICGC	LQERGSR	SCF_FBXL2	227:233	Mutation rewiring degron network	0.0556
p.G215V	DO229036	LICA	ICGC	LHNTPYGT	DEG_SCF_FBW7_1	209:216	Mutation altering degron motif	0.6421
p.G215V	DO229035	LICA	ICGC	LHNTPYGT	DEG_SCF_FBW7_1	209:216	Mutation altering degron motif	0.6421
p.A231V	DO228138	PBCA	ICGC	LQERGSR	SCF_FBXL2	227:233	Mutation altering degron motif	0.6936
p.R200K	DO47331	SKCM	ICGC	LHNTPYGT	DEG_SCF_FBW7_1	209:216	Mutation rewiring degron network	0.0833
p.E223D	DO222401	STAD	ICGC	LHNTPYGT	DEG_SCF_FBW7_1	209:216	Mutation blocking ubiquitination signal	0.5833
p.E223D	DO222401	STAD	ICGC	LQERGSR	SCF_FBXL2	227:233	Mutation blocking ubiquitination signal	0.6667
p.G215D	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	LHNTPYGT	DEG_SCF_FBW7_1	209:216	Mutation altering degron motif	0.6087
p.G215D	ACH-002272	Lymphoma	CCLE	LHNTPYGT	DEG_SCF_FBW7_1	209:216	Mutation altering degron motif	0.6087
p.G215D	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	LHNTPYGT	DEG_SCF_FBW7_1	209:216	Mutation altering degron motif	0.6087
p.R230Q	SIDM00002	Neuroblastoma	GDSC	LQERGSR	SCF_FBXL2	227:233	Mutation altering degron motif	0.7329
p.R230Q	ACH-002340	Neuroblastoma	CCLE	LQERGSR	SCF_FBXL2	227:233	Mutation altering degron motif	0.7329
p.R230Q	NBsusSR	autonomic ganglia	COSMIC	LQERGSR	SCF_FBXL2	227:233	Mutation altering degron motif	0.7329
p.A217V	SIDM00487	Colorectal Carcinoma	GDSC	LHNTPYGT	DEG_SCF_FBW7_1	209:216	Mutation rewiring degron network	0.3056
p.A217V	SIDM00487	Colorectal Carcinoma	GDSC	LQERGSR	SCF_FBXL2	227:233	Mutation rewiring degron network	0.0556
p.A217V	ACH-000963	Colon/Colorectal Cancer	CCLE	LHNTPYGT	DEG_SCF_FBW7_1	209:216	Mutation rewiring degron network	0.3056
p.A217V	ACH-000963	Colon/Colorectal Cancer	CCLE	LQERGSR	SCF_FBXL2	227:233	Mutation rewiring degron network	0.0556
p.A217V	CCK-81	large intestine	COSMIC	LHNTPYGT	DEG_SCF_FBW7_1	209:216	Mutation rewiring degron network	0.3056
p.A217V	CCK-81	large intestine	COSMIC	LQERGSR	SCF_FBXL2	227:233	Mutation rewiring degron network	0.0556
p.E229Q	SIDM00240	Cervical Carcinoma	GDSC	LQERGSR	SCF_FBXL2	227:233	Mutation altering degron motif	0.5633
p.E229Q	ACH-002180	Cervical Cancer	CCLE	LQERGSR	SCF_FBXL2	227:233	Mutation altering degron motif	0.5633
p.E229Q	OMC-1	cervix	COSMIC	LQERGSR	SCF_FBXL2	227:233	Mutation altering degron motif	0.5633
p.I239V	LNZTA3WT4	central nervous system	COSMIC	LQERGSR	SCF_FBXL2	227:233	Mutation rewiring degron network	0.1667
p.R205G	RS4-11	haematopoietic and lymphoid tissue	COSMIC	LHNTPYGT	DEG_SCF_FBW7_1	209:216	Mutation rewiring degron network	0.2222
p.P219L	HT-1080	soft tissue	COSMIC	LHNTPYGT	DEG_SCF_FBW7_1	209:216	Mutation rewiring degron network	0.25
p.P219L	HT-1080	soft tissue	COSMIC	LQERGSR	SCF_FBXL2	227:233	Mutation rewiring degron network	0.1111

Kaplan plot for KCTD5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KCTD5

UniProt ID: Q9NXV2

Entrez ID: 54442

Protein name: BTB/POZ domain-containing protein KCTD5

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KCTD5 in