DegronMD

Uniprot ID: Q9NXV2

Source protein: BTB/POZ domain-containing protein KCTD5

Source gene: KCTD5

Class: SCF_FBXL2

Location: 227:233

E3 ligase: FBXL2

DEGRON score: 0.9287

ASA_SCORE: 108.8714

COIL: 0.4921

CONS_SCORE: 0.5092

DSS_SCORE: 0.841

HELIX: 0.4914

FCONS_SCORE: 1.0322

RIG_SCORE: 0.7061

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S232L	TCGA-EE-A2MF	SKCM	TCGA	LQERGSR	SCF_FBXL2	0.6556
p.S232L	DO222491	MELA	ICGC	LQERGSR	SCF_FBXL2	0.6556
p.S232L	DO51249	SKCM	ICGC	LQERGSR	SCF_FBXL2	0.6556
p.G231S	TCGA-EE-A3J5	SKCM	TCGA	LQERGSR	SCF_FBXL2	0.6993
p.E223Q	DO14252	HNSC	ICGC	LQERGSR	SCF_FBXL2	0.6667
p.V217F	DO228976	LICA	ICGC	LQERGSR	SCF_FBXL2	0.0556
p.A231V	DO228138	PBCA	ICGC	LQERGSR	SCF_FBXL2	0.6936
p.E223D	DO222401	STAD	ICGC	LQERGSR	SCF_FBXL2	0.6667
p.R230Q	SIDM00002	Neuroblastoma	GDSC	LQERGSR	SCF_FBXL2	0.7329
p.R230Q	ACH-002340	Neuroblastoma	CCLE	LQERGSR	SCF_FBXL2	0.7329
p.R230Q	NBsusSR	autonomic_ganglia	COSMIC	LQERGSR	SCF_FBXL2	0.7329
p.A217V	SIDM00487	Colorectal Carcinoma	GDSC	LQERGSR	SCF_FBXL2	0.0556
p.A217V	ACH-000963	Colon/Colorectal Cancer	CCLE	LQERGSR	SCF_FBXL2	0.0556
p.A217V	CCK-81	large_intestine	COSMIC	LQERGSR	SCF_FBXL2	0.0556
p.E229Q	SIDM00240	Cervical Carcinoma	GDSC	LQERGSR	SCF_FBXL2	0.5633
p.E229Q	ACH-002180	Cervical Cancer	CCLE	LQERGSR	SCF_FBXL2	0.5633
p.E229Q	OMC-1	cervix	COSMIC	LQERGSR	SCF_FBXL2	0.5633
p.I239V	LNZTA3WT4	central_nervous_system	COSMIC	LQERGSR	SCF_FBXL2	0.1667
p.P219L	HT-1080	soft_tissue	COSMIC	LQERGSR	SCF_FBXL2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NXV2	BTB/POZ domain-containing protein KCTD5	SCF_FBXL2	227:233	LQERGSR	FBXL2	0.9287	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons