DegronMD

Uniprot ID: Q53SF7

Source protein: Cordon-bleu protein-like 1

Source gene: COBLL1

Class: LIG_APCC_ABBA_1

Location: 663:668

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.526

ASA_SCORE: 106.2333

COIL: 0.8645

CONS_SCORE: 0.4456

DSS_SCORE: 0.4441

HELIX: 0.0238

FCONS_SCORE: 1.0862

RIG_SCORE: 0.7464

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P667A	SIDM00345	Non-Small Cell Lung Carcinoma	GDSC	LIIHSE	LIG_APCC_ABBA_1	0.7503
p.P667A	LCLC-103H	lung	COSMIC	LIIHSE	LIG_APCC_ABBA_1	0.7503
p.C668Y	ACH-000985	Colon/Colorectal Cancer	CCLE	LIIHSE	LIG_APCC_ABBA_1	0.7087
p.C668Y	LS-411N	large_intestine	COSMIC	LIIHSE	LIG_APCC_ABBA_1	0.7087
p.D669Y	DO41199	UCEC	ICGC	LIIHSE	LIG_APCC_ABBA_1	0.3056
p.Q670R	DO50850	LIRI	ICGC	LIIHSE	LIG_APCC_ABBA_1	0.2778
p.D661Y	SIDM01150	Non-Small Cell Lung Carcinoma	GDSC	LIIHSE	LIG_APCC_ABBA_1	0.2778
p.D661Y	NCI-H838	lung	COSMIC	LIIHSE	LIG_APCC_ABBA_1	0.2778
p.P670L	HuP-T4	pancreas	COSMIC	LIIHSE	LIG_APCC_ABBA_1	0.2778
p.T671I	ACH-001550	Skin Cancer	CCLE	LIIHSE	LIG_APCC_ABBA_1	0.25
p.T671I	MCC13	skin	COSMIC	LIIHSE	LIG_APCC_ABBA_1	0.25
p.V673L	DO225209	BRCA	ICGC	LIIHSE	LIG_APCC_ABBA_1	0.1944
p.V673I	DO49767	KIRP	ICGC	LIIHSE	LIG_APCC_ABBA_1	0.1944
p.V673I	DO38887	STAD	ICGC	LIIHSE	LIG_APCC_ABBA_1	0.1944
p.D657Y	TCGA-BR-8680	STAD	TCGA	LIIHSE	LIG_APCC_ABBA_1	0.1667
p.D657Y	DO47769	STAD	ICGC	LIIHSE	LIG_APCC_ABBA_1	0.1667
p.D657V	ACH-001365	Lung Cancer	CCLE	LIIHSE	LIG_APCC_ABBA_1	0.1667
p.D657V	NCI-H847	lung	COSMIC	LIIHSE	LIG_APCC_ABBA_1	0.1667
p.D675Y	DO222884	COCA	ICGC	LIIHSE	LIG_APCC_ABBA_1	0.1389
p.D675Y	DO42312	UCEC	ICGC	LIIHSE	LIG_APCC_ABBA_1	0.1389
p.T678I	ACH-000999	Colon/Colorectal Cancer	CCLE	LIIHSE	LIG_APCC_ABBA_1	0.0556
p.T678I	SNU-1040	large_intestine	COSMIC	LIIHSE	LIG_APCC_ABBA_1	0.0556
p.K653R	SK-OV-3	ovary	COSMIC	LIIHSE	LIG_APCC_ABBA_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53SF7	Cordon-bleu protein-like 1	LIG_APCC_ABBA_1	663:668	LIIHSE	APC,CDC20,FZR1	0.526	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons