DegronMD

Uniprot ID: P01024

Source protein: Complement C3

Source gene: C3

Class: LIG_APCC_ABBA_1

Location: 1444:1449

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5946

ASA_SCORE: 11.15

COIL: 0.0573

CONS_SCORE: 0.5021

DSS_SCORE: 0.0891

HELIX: 0.0035

FCONS_SCORE: 1.2741

RIG_SCORE: 0.9217

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N1442T	TCGA-27-2528	GBM	TCGA	LIIYLD	LIG_APCC_ABBA_1	0.2778
p.N1442T	DO11782	GBM	ICGC	LIIYLD	LIG_APCC_ABBA_1	0.2778
p.Y1447H	TCGA-BP-4998	KIRC	TCGA	LIIYLD	LIG_APCC_ABBA_1	0.6118
p.Y1447H	DO20210	KIRC	ICGC	LIIYLD	LIG_APCC_ABBA_1	0.6118
p.A1437T	TCGA-DA-A960	SKCM	TCGA	LIIYLD	LIG_APCC_ABBA_1	0.1389
p.A1437T	DO219482	SKCM	ICGC	LIIYLD	LIG_APCC_ABBA_1	0.1389
p.D1440N	TCGA-GN-A4U3	SKCM	TCGA	LIIYLD	LIG_APCC_ABBA_1	0.2222
p.D1440N	DO219484	SKCM	ICGC	LIIYLD	LIG_APCC_ABBA_1	0.2222
p.S1454C	TCGA-S5-AA26	BLCA	TCGA	LIIYLD	LIG_APCC_ABBA_1	0.1944
p.S1454C	DO51904	BLCA	ICGC	LIIYLD	LIG_APCC_ABBA_1	0.1944
p.V1451A	DO222503	COCA	ICGC	LIIYLD	LIG_APCC_ABBA_1	0.2778
p.D1449V	DO233759	GACA	ICGC	LIIYLD	LIG_APCC_ABBA_1	0.7785
p.R1441K	SIDM00014	Colorectal Carcinoma	GDSC	LIIYLD	LIG_APCC_ABBA_1	0.25
p.R1441K	LIM1215	large_intestine	COSMIC	LIIYLD	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P01024	Complement C3	LIG_APCC_ABBA_1	1444:1449	LIIYLD	APC,CDC20,FZR1	0.5946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons