DegronMD

Uniprot ID: A8MTB9

Source protein: Carcinoembryonic antigen-related cell adhesion molecule 18

Source gene: CEACAM18

Class: LIG_APCC_ABBA_1

Location: 305:310

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9366

ASA_SCORE: 81.5

COIL: 0.1357

CONS_SCORE: 0.7524

DSS_SCORE: 0.1721

HELIX: 0.0023

FCONS_SCORE: 1.2023

RIG_SCORE: 0.9274

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E315G	TCGA-BH-A0BP	BRCA	TCGA	LIMYMD	LIG_APCC_ABBA_1	0.1944
p.E315G	DO4056	BRCA	ICGC	LIMYMD	LIG_APCC_ABBA_1	0.1944
p.M314I	TCGA-CV-7568	HNSC	TCGA	LIMYMD	LIG_APCC_ABBA_1	0.2222
p.M314I	DO14160	HNSC	ICGC	LIMYMD	LIG_APCC_ABBA_1	0.2222
p.D299A	TCGA-EE-A29L	SKCM	TCGA	LIMYMD	LIG_APCC_ABBA_1	0.1667
p.D299A	DO222599	MELA	ICGC	LIMYMD	LIG_APCC_ABBA_1	0.1667
p.D299A	DO37835	SKCM	ICGC	LIMYMD	LIG_APCC_ABBA_1	0.1667
p.S320F	TCGA-EE-A2MJ	SKCM	TCGA	LIMYMD	LIG_APCC_ABBA_1	0.0556
p.S320F	DO218900	SKCA	ICGC	LIMYMD	LIG_APCC_ABBA_1	0.0556
p.S320F	DO38099	SKCM	ICGC	LIMYMD	LIG_APCC_ABBA_1	0.0556
p.P297L	TCGA-ER-A193	SKCM	TCGA	LIMYMD	LIG_APCC_ABBA_1	0.1111
p.P297L	DO47368	SKCM	ICGC	LIMYMD	LIG_APCC_ABBA_1	0.1111
p.G309S	TCGA-FS-A4F0	SKCM	TCGA	LIMYMD	LIG_APCC_ABBA_1	0.6993
p.G309S	DO37891	SKCM	ICGC	LIMYMD	LIG_APCC_ABBA_1	0.6993
p.G309D	TCGA-FS-A4F0	SKCM	TCGA	LIMYMD	LIG_APCC_ABBA_1	0.7198
p.G309D	DO37891	SKCM	ICGC	LIMYMD	LIG_APCC_ABBA_1	0.7198
p.I303T	TCGA-ND-A4WC	UCS	TCGA	LIMYMD	LIG_APCC_ABBA_1	0.2778
p.L320I	DO227935	BRCA	ICGC	LIMYMD	LIG_APCC_ABBA_1	0.0556
p.D298G	DO222798	COCA	ICGC	LIMYMD	LIG_APCC_ABBA_1	0.1389
p.N296T	DO234413	ESAD	ICGC	LIMYMD	LIG_APCC_ABBA_1	0.0833
p.G302S	DO233769	GACA	ICGC	LIMYMD	LIG_APCC_ABBA_1	0.25
p.G302S	DO224724	PACA	ICGC	LIMYMD	LIG_APCC_ABBA_1	0.25
p.D299Y	DO231124	LUSC	ICGC	LIMYMD	LIG_APCC_ABBA_1	0.1667
p.D319N	DO220873	MELA	ICGC	LIMYMD	LIG_APCC_ABBA_1	0.0833
p.C296F	SIDM00973	Melanoma	GDSC	LIMYMD	LIG_APCC_ABBA_1	0.0833
p.P316H	SIDM00630	Breast Carcinoma	GDSC	LIMYMD	LIG_APCC_ABBA_1	0.1667
p.P316H	ACH-000876	Breast Cancer	CCLE	LIMYMD	LIG_APCC_ABBA_1	0.1667
p.Q314R	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LIMYMD	LIG_APCC_ABBA_1	0.2222
p.Q314R	SIDM01263	T-Lymphoblastic Leukemia	GDSC	LIMYMD	LIG_APCC_ABBA_1	0.2222
p.N300K	SIDM01004	Chronic Myelogenous Leukemia	GDSC	LIMYMD	LIG_APCC_ABBA_1	0.1944
p.N300K	ACH-000983	Leukemia	CCLE	LIMYMD	LIG_APCC_ABBA_1	0.1944
p.N300K	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	LIMYMD	LIG_APCC_ABBA_1	0.1944
p.C296G	SIDM00059	Ovarian Carcinoma	GDSC	LIMYMD	LIG_APCC_ABBA_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LIMYMD

Degron related mutations and impact score

Drug responses associated with CEACAM18 mutations

All proteins holding degron of LIMYMD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8MTB9	Carcinoembryonic antigen-related cell adhesion molecule 18	LIG_APCC_ABBA_1	305:310	LIMYMD	APC,CDC20,FZR1	0.9366	More...