DegronMD

Uniprot ID: A8MTB9

Source protein: Carcinoembryonic antigen-related cell adhesion molecule 18

Source gene: CEACAM18

Class: LIG_APCC_ABBA_1

Location: 305:310

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9366

ASA_SCORE: 81.5

COIL: 0.1357

CONS_SCORE: 0.7524

DSS_SCORE: 0.1721

HELIX: 0.0023

FCONS_SCORE: 1.2023

RIG_SCORE: 0.9274

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G309D	TCGA-FS-A4F0	SKCM	TCGA	LIMYMD	LIG_APCC_ABBA_1	0.7198
p.G309D	DO37891	SKCM	ICGC	LIMYMD	LIG_APCC_ABBA_1	0.7198
p.G309S	TCGA-FS-A4F0	SKCM	TCGA	LIMYMD	LIG_APCC_ABBA_1	0.6993
p.G309S	DO37891	SKCM	ICGC	LIMYMD	LIG_APCC_ABBA_1	0.6993
p.I303T	TCGA-ND-A4WC	UCS	TCGA	LIMYMD	LIG_APCC_ABBA_1	0.2778
p.G302S	DO233769	GACA	ICGC	LIMYMD	LIG_APCC_ABBA_1	0.25
p.G302S	DO224724	PACA	ICGC	LIMYMD	LIG_APCC_ABBA_1	0.25
p.M314I	TCGA-CV-7568	HNSC	TCGA	LIMYMD	LIG_APCC_ABBA_1	0.2222
p.M314I	DO14160	HNSC	ICGC	LIMYMD	LIG_APCC_ABBA_1	0.2222
p.Q314R	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LIMYMD	LIG_APCC_ABBA_1	0.2222
p.Q314R	SIDM01263	T-Lymphoblastic Leukemia	GDSC	LIMYMD	LIG_APCC_ABBA_1	0.2222
p.E315G	TCGA-BH-A0BP	BRCA	TCGA	LIMYMD	LIG_APCC_ABBA_1	0.1944
p.E315G	DO4056	BRCA	ICGC	LIMYMD	LIG_APCC_ABBA_1	0.1944
p.N300K	SIDM01004	Chronic Myelogenous Leukemia	GDSC	LIMYMD	LIG_APCC_ABBA_1	0.1944
p.N300K	ACH-000983	Leukemia	CCLE	LIMYMD	LIG_APCC_ABBA_1	0.1944
p.N300K	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	LIMYMD	LIG_APCC_ABBA_1	0.1944
p.D299A	TCGA-EE-A29L	SKCM	TCGA	LIMYMD	LIG_APCC_ABBA_1	0.1667
p.D299A	DO222599	MELA	ICGC	LIMYMD	LIG_APCC_ABBA_1	0.1667
p.D299A	DO37835	SKCM	ICGC	LIMYMD	LIG_APCC_ABBA_1	0.1667
p.D299Y	DO231124	LUSC	ICGC	LIMYMD	LIG_APCC_ABBA_1	0.1667
p.P316H	SIDM00630	Breast Carcinoma	GDSC	LIMYMD	LIG_APCC_ABBA_1	0.1667
p.P316H	ACH-000876	Breast Cancer	CCLE	LIMYMD	LIG_APCC_ABBA_1	0.1667
p.D298G	DO222798	COCA	ICGC	LIMYMD	LIG_APCC_ABBA_1	0.1389
p.P297L	TCGA-ER-A193	SKCM	TCGA	LIMYMD	LIG_APCC_ABBA_1	0.1111
p.P297L	DO47368	SKCM	ICGC	LIMYMD	LIG_APCC_ABBA_1	0.1111

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8MTB9	Carcinoembryonic antigen-related cell adhesion molecule 18	LIG_APCC_ABBA_1	305:310	LIMYMD	APC,CDC20,FZR1	0.9366	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons