DegronMD - A8MTB9(CEACAM18)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H327R	TCGA-AA-3947	COAD	TCGA	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.25
p.H327R	DO8192	COAD	ICGC	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.25
p.D339Y	TCGA-AX-A06F	UCEC	TCGA	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.2222
p.D339Y	DO41752	UCEC	ICGC	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.2222
p.E315G	TCGA-BH-A0BP	BRCA	TCGA	LIMYMD	LIG_APCC_ABBA_1	305:310	Mutation rewiring degron network	0.1944
p.E315G	DO4056	BRCA	ICGC	LIMYMD	LIG_APCC_ABBA_1	305:310	Mutation rewiring degron network	0.1944
p.F321V	TCGA-BR-4357	STAD	TCGA	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.0833
p.F321V	TCGA-D5-6931	COAD	TCGA	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.0833
p.F321V	DO8384	COAD	ICGC	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.0833
p.F321V	DO233748	GACA	ICGC	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.0833
p.F321V	DO38241	STAD	ICGC	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.0833
p.M314I	TCGA-CV-7568	HNSC	TCGA	LIMYMD	LIG_APCC_ABBA_1	305:310	Mutation rewiring degron network	0.2222
p.M314I	DO14160	HNSC	ICGC	LIMYMD	LIG_APCC_ABBA_1	305:310	Mutation rewiring degron network	0.2222
p.S333F	TCGA-D3-A51G	SKCM	TCGA	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation altering degron motif	0.7982
p.S333F	TCGA-LH-A9QB	SKCM	TCGA	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation altering degron motif	0.7982
p.S333F	DO47700	SKCM	ICGC	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation altering degron motif	0.7982
p.S333F	DO51266	SKCM	ICGC	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation altering degron motif	0.7982
p.N336S	TCGA-DA-A1I7	SKCM	TCGA	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.3056
p.N336S	DO37951	SKCM	ICGC	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.3056
p.M342I	TCGA-EE-A29D	SKCM	TCGA	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.1389
p.M342I	DO38123	SKCM	ICGC	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.1389
p.D299A	TCGA-EE-A29L	SKCM	TCGA	LIMYMD	LIG_APCC_ABBA_1	305:310	Mutation rewiring degron network	0.1667
p.D299A	DO222599	MELA	ICGC	LIMYMD	LIG_APCC_ABBA_1	305:310	Mutation rewiring degron network	0.1667
p.D299A	DO37835	SKCM	ICGC	LIMYMD	LIG_APCC_ABBA_1	305:310	Mutation rewiring degron network	0.1667
p.S320F	TCGA-EE-A2MJ	SKCM	TCGA	LIMYMD	LIG_APCC_ABBA_1	305:310	Mutation rewiring degron network	0.0556
p.S320F	TCGA-EE-A2MJ	SKCM	TCGA	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.0556
p.S320F	DO218900	SKCA	ICGC	LIMYMD	LIG_APCC_ABBA_1	305:310	Mutation rewiring degron network	0.0556
p.S320F	DO218900	SKCA	ICGC	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.0556
p.S320F	DO38099	SKCM	ICGC	LIMYMD	LIG_APCC_ABBA_1	305:310	Mutation rewiring degron network	0.0556
p.S320F	DO38099	SKCM	ICGC	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.0556
p.P297L	TCGA-ER-A193	SKCM	TCGA	LIMYMD	LIG_APCC_ABBA_1	305:310	Mutation rewiring degron network	0.1111
p.P297L	DO47368	SKCM	ICGC	LIMYMD	LIG_APCC_ABBA_1	305:310	Mutation rewiring degron network	0.1111
p.G309S	TCGA-FS-A4F0	SKCM	TCGA	LIMYMD	LIG_APCC_ABBA_1	305:310	Mutation altering degron motif	0.6993
p.G309S	DO37891	SKCM	ICGC	LIMYMD	LIG_APCC_ABBA_1	305:310	Mutation altering degron motif	0.6993
p.G309D	TCGA-FS-A4F0	SKCM	TCGA	LIMYMD	LIG_APCC_ABBA_1	305:310	Mutation altering degron motif	0.7198
p.G309D	DO37891	SKCM	ICGC	LIMYMD	LIG_APCC_ABBA_1	305:310	Mutation altering degron motif	0.7198
p.I303T	TCGA-ND-A4WC	UCS	TCGA	LIMYMD	LIG_APCC_ABBA_1	305:310	Mutation rewiring degron network	0.2778
p.L334V	TCGA-XC-AA0X	LUSC	TCGA	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation altering degron motif	0.6765
p.L334V	DO52026	LUSC	ICGC	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation altering degron motif	0.6765
p.L320I	DO227935	BRCA	ICGC	LIMYMD	LIG_APCC_ABBA_1	305:310	Mutation rewiring degron network	0.0556
p.L320I	DO227935	BRCA	ICGC	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.0556
p.D298G	DO222798	COCA	ICGC	LIMYMD	LIG_APCC_ABBA_1	305:310	Mutation rewiring degron network	0.1389
p.N296T	DO234413	ESAD	ICGC	LIMYMD	LIG_APCC_ABBA_1	305:310	Mutation rewiring degron network	0.0833
p.G302S	DO233769	GACA	ICGC	LIMYMD	LIG_APCC_ABBA_1	305:310	Mutation rewiring degron network	0.25
p.G302S	DO224724	PACA	ICGC	LIMYMD	LIG_APCC_ABBA_1	305:310	Mutation rewiring degron network	0.25
p.S345W	DO233925	GACA	ICGC	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.0556
p.W345S	DO230659	LAML	ICGC	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.0556
p.W345S	SIDM00251	Gastric Carcinoma	GDSC	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.0556
p.W345S	SIDM00618	Hepatocellular Carcinoma	GDSC	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.0556
p.G334V	DO229045	LICA	ICGC	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation altering degron motif	0.6421
p.D299Y	DO231124	LUSC	ICGC	LIMYMD	LIG_APCC_ABBA_1	305:310	Mutation rewiring degron network	0.1667
p.D319N	DO220873	MELA	ICGC	LIMYMD	LIG_APCC_ABBA_1	305:310	Mutation rewiring degron network	0.0833
p.H339Y	DO220895	MELA	ICGC	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.2222
p.L324F	DO222363	MELA	ICGC	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.1667
p.A343V	DO228138	PBCA	ICGC	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.1111
p.P324L	DO229491	SKCA	ICGC	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.1667
p.P324L	ACH-000676	Brain Cancer	CCLE	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.1667
p.R331M	SIDM01943	Colorectal Carcinoma	GDSC	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation altering degron motif	0.7521
p.C296F	SIDM00973	Melanoma	GDSC	LIMYMD	LIG_APCC_ABBA_1	305:310	Mutation rewiring degron network	0.0833
p.P316H	SIDM00630	Breast Carcinoma	GDSC	LIMYMD	LIG_APCC_ABBA_1	305:310	Mutation rewiring degron network	0.1667
p.P316H	ACH-000876	Breast Cancer	CCLE	LIMYMD	LIG_APCC_ABBA_1	305:310	Mutation rewiring degron network	0.1667
p.Q314R	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LIMYMD	LIG_APCC_ABBA_1	305:310	Mutation rewiring degron network	0.2222
p.Q314R	SIDM01263	T-Lymphoblastic Leukemia	GDSC	LIMYMD	LIG_APCC_ABBA_1	305:310	Mutation rewiring degron network	0.2222
p.N300K	SIDM01004	Chronic Myelogenous Leukemia	GDSC	LIMYMD	LIG_APCC_ABBA_1	305:310	Mutation rewiring degron network	0.1944
p.N300K	ACH-000983	Leukemia	CCLE	LIMYMD	LIG_APCC_ABBA_1	305:310	Mutation rewiring degron network	0.1944
p.N300K	KCL-22	haematopoietic and lymphoid tissue	COSMIC	LIMYMD	LIG_APCC_ABBA_1	305:310	Mutation rewiring degron network	0.1944
p.C322R	SIDM00007	Other Solid Cancers	GDSC	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.1111
p.C322R	ACH-001550	Skin Cancer	CCLE	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.1111
p.C322F	SIDM00007	Other Solid Cancers	GDSC	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.1111
p.C322F	ACH-001550	Skin Cancer	CCLE	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.1111
p.P324S	SIDM00070	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.1667
p.C296G	SIDM00059	Ovarian Carcinoma	GDSC	LIMYMD	LIG_APCC_ABBA_1	305:310	Mutation rewiring degron network	0.0833
p.G344W	ACH-000666	Lung Cancer	CCLE	LRIHGD	LIG_APCC_ABBA_1	330:335	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CEACAM18

UniProt ID: A8MTB9

Entrez ID:

Protein name: Carcinoembryonic antigen-related cell adhesion molecule 18

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CEACAM18 in