DegronMD

Uniprot ID: A8MTB9

Source protein: Carcinoembryonic antigen-related cell adhesion molecule 18

Source gene: CEACAM18

Class: LIG_APCC_ABBA_1

Location: 330:335

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8273

ASA_SCORE: 44.25

COIL: 0.219

CONS_SCORE: 0.926

DSS_SCORE: 0.1764

HELIX: 0.0035

FCONS_SCORE: 1.3711

RIG_SCORE: 0.7484

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H327R	TCGA-AA-3947	COAD	TCGA	LRIHGD	LIG_APCC_ABBA_1	0.25
p.H327R	DO8192	COAD	ICGC	LRIHGD	LIG_APCC_ABBA_1	0.25
p.D339Y	TCGA-AX-A06F	UCEC	TCGA	LRIHGD	LIG_APCC_ABBA_1	0.2222
p.D339Y	DO41752	UCEC	ICGC	LRIHGD	LIG_APCC_ABBA_1	0.2222
p.F321V	TCGA-BR-4357	STAD	TCGA	LRIHGD	LIG_APCC_ABBA_1	0.0833
p.F321V	TCGA-D5-6931	COAD	TCGA	LRIHGD	LIG_APCC_ABBA_1	0.0833
p.F321V	DO8384	COAD	ICGC	LRIHGD	LIG_APCC_ABBA_1	0.0833
p.F321V	DO233748	GACA	ICGC	LRIHGD	LIG_APCC_ABBA_1	0.0833
p.F321V	DO38241	STAD	ICGC	LRIHGD	LIG_APCC_ABBA_1	0.0833
p.S333F	TCGA-D3-A51G	SKCM	TCGA	LRIHGD	LIG_APCC_ABBA_1	0.7982
p.S333F	TCGA-LH-A9QB	SKCM	TCGA	LRIHGD	LIG_APCC_ABBA_1	0.7982
p.S333F	DO47700	SKCM	ICGC	LRIHGD	LIG_APCC_ABBA_1	0.7982
p.S333F	DO51266	SKCM	ICGC	LRIHGD	LIG_APCC_ABBA_1	0.7982
p.N336S	TCGA-DA-A1I7	SKCM	TCGA	LRIHGD	LIG_APCC_ABBA_1	0.3056
p.N336S	DO37951	SKCM	ICGC	LRIHGD	LIG_APCC_ABBA_1	0.3056
p.M342I	TCGA-EE-A29D	SKCM	TCGA	LRIHGD	LIG_APCC_ABBA_1	0.1389
p.M342I	DO38123	SKCM	ICGC	LRIHGD	LIG_APCC_ABBA_1	0.1389
p.S320F	TCGA-EE-A2MJ	SKCM	TCGA	LRIHGD	LIG_APCC_ABBA_1	0.0556
p.S320F	DO218900	SKCA	ICGC	LRIHGD	LIG_APCC_ABBA_1	0.0556
p.S320F	DO38099	SKCM	ICGC	LRIHGD	LIG_APCC_ABBA_1	0.0556
p.L334V	TCGA-XC-AA0X	LUSC	TCGA	LRIHGD	LIG_APCC_ABBA_1	0.6765
p.L334V	DO52026	LUSC	ICGC	LRIHGD	LIG_APCC_ABBA_1	0.6765
p.L320I	DO227935	BRCA	ICGC	LRIHGD	LIG_APCC_ABBA_1	0.0556
p.S345W	DO233925	GACA	ICGC	LRIHGD	LIG_APCC_ABBA_1	0.0556
p.W345S	DO230659	LAML	ICGC	LRIHGD	LIG_APCC_ABBA_1	0.0556
p.W345S	SIDM00251	Gastric Carcinoma	GDSC	LRIHGD	LIG_APCC_ABBA_1	0.0556
p.W345S	SIDM00618	Hepatocellular Carcinoma	GDSC	LRIHGD	LIG_APCC_ABBA_1	0.0556
p.G334V	DO229045	LICA	ICGC	LRIHGD	LIG_APCC_ABBA_1	0.6421
p.H339Y	DO220895	MELA	ICGC	LRIHGD	LIG_APCC_ABBA_1	0.2222
p.L324F	DO222363	MELA	ICGC	LRIHGD	LIG_APCC_ABBA_1	0.1667
p.A343V	DO228138	PBCA	ICGC	LRIHGD	LIG_APCC_ABBA_1	0.1111
p.P324L	DO229491	SKCA	ICGC	LRIHGD	LIG_APCC_ABBA_1	0.1667
p.P324L	ACH-000676	Brain Cancer	CCLE	LRIHGD	LIG_APCC_ABBA_1	0.1667
p.R331M	SIDM01943	Colorectal Carcinoma	GDSC	LRIHGD	LIG_APCC_ABBA_1	0.7521
p.C322R	SIDM00007	Other Solid Cancers	GDSC	LRIHGD	LIG_APCC_ABBA_1	0.1111
p.C322R	ACH-001550	Skin Cancer	CCLE	LRIHGD	LIG_APCC_ABBA_1	0.1111
p.C322F	SIDM00007	Other Solid Cancers	GDSC	LRIHGD	LIG_APCC_ABBA_1	0.1111
p.C322F	ACH-001550	Skin Cancer	CCLE	LRIHGD	LIG_APCC_ABBA_1	0.1111
p.P324S	SIDM00070	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRIHGD	LIG_APCC_ABBA_1	0.1667
p.G344W	ACH-000666	Lung Cancer	CCLE	LRIHGD	LIG_APCC_ABBA_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRIHGD

Degron related mutations and impact score

Drug responses associated with CEACAM18 mutations

All proteins holding degron of LRIHGD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8MTB9	Carcinoembryonic antigen-related cell adhesion molecule 18	LIG_APCC_ABBA_1	330:335	LRIHGD	APC,CDC20,FZR1	0.8273	More...