DegronMD

Uniprot ID: Q01664

Source protein: Transcription factor AP-4

Source gene: TFAP4

Class: LIG_APCC_ABBA_1

Location: 74:79

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9613

ASA_SCORE: 57.8833

COIL: 0.8687

CONS_SCORE: 0.6121

DSS_SCORE: 0.3633

HELIX: 0.1037

FCONS_SCORE: 0.778

RIG_SCORE: 0.7453

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K82N	TCGA-A5-A1OF	UCEC	TCGA	LIPHTD	LIG_APCC_ABBA_1	0.3611
p.K82N	DO42568	UCEC	ICGC	LIPHTD	LIG_APCC_ABBA_1	0.3611
p.A66T	TCGA-AJ-A3EK	UCEC	TCGA	LIPHTD	LIG_APCC_ABBA_1	0.1111
p.A66T	TCGA-AX-A1C4	UCEC	TCGA	LIPHTD	LIG_APCC_ABBA_1	0.1111
p.A66T	DO41584	UCEC	ICGC	LIPHTD	LIG_APCC_ABBA_1	0.1111
p.A66T	DO42480	UCEC	ICGC	LIPHTD	LIG_APCC_ABBA_1	0.1111
p.N65S	TCGA-AN-A0AT	BRCA	TCGA	LIPHTD	LIG_APCC_ABBA_1	0.0833
p.N65S	DO2783	BRCA	ICGC	LIPHTD	LIG_APCC_ABBA_1	0.0833
p.N65S	SIDM01259	B-Lymphoblastic Leukemia	GDSC	LIPHTD	LIG_APCC_ABBA_1	0.0833
p.N65S	ACH-001669	Leukemia	CCLE	LIPHTD	LIG_APCC_ABBA_1	0.0833
p.N65S	ACH-002238	Leukemia	CCLE	LIPHTD	LIG_APCC_ABBA_1	0.0833
p.N65S	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	LIPHTD	LIG_APCC_ABBA_1	0.0833
p.H77N	DO229025	LICA	ICGC	LIPHTD	LIG_APCC_ABBA_1	0.7423
p.K85R	DO218697	ORCA	ICGC	LIPHTD	LIG_APCC_ABBA_1	0.2778
p.I88T	ACH-000088	Non-Cancerous	CCLE	LIPHTD	LIG_APCC_ABBA_1	0.0833
p.I75L	ACH-000660	Lymphoma	CCLE	LIPHTD	LIG_APCC_ABBA_1	0.6063
p.I75L	SU-DHL-5	haematopoietic_and_lymphoid_tissue	COSMIC	LIPHTD	LIG_APCC_ABBA_1	0.6063

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01664	Transcription factor AP-4	LIG_APCC_ABBA_1	74:79	LIPHTD	APC,CDC20,FZR1	0.9613	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons