DegronMD - Q01664(TFAP4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K82N	TCGA-A5-A1OF	UCEC	TCGA	LIPHTD	LIG_APCC_ABBA_1	74:79	Mutation substituting flanking lysine	0.3611
p.K82N	DO42568	UCEC	ICGC	LIPHTD	LIG_APCC_ABBA_1	74:79	Mutation substituting flanking lysine	0.3611
p.A66T	TCGA-AJ-A3EK	UCEC	TCGA	LIPHTD	LIG_APCC_ABBA_1	74:79	Mutation rewiring degron network	0.1111
p.A66T	TCGA-AX-A1C4	UCEC	TCGA	LIPHTD	LIG_APCC_ABBA_1	74:79	Mutation rewiring degron network	0.1111
p.A66T	DO41584	UCEC	ICGC	LIPHTD	LIG_APCC_ABBA_1	74:79	Mutation rewiring degron network	0.1111
p.A66T	DO42480	UCEC	ICGC	LIPHTD	LIG_APCC_ABBA_1	74:79	Mutation rewiring degron network	0.1111
p.N65S	TCGA-AN-A0AT	BRCA	TCGA	LIPHTD	LIG_APCC_ABBA_1	74:79	Mutation rewiring degron network	0.0833
p.N65S	DO2783	BRCA	ICGC	LIPHTD	LIG_APCC_ABBA_1	74:79	Mutation rewiring degron network	0.0833
p.N65S	SIDM01259	B-Lymphoblastic Leukemia	GDSC	LIPHTD	LIG_APCC_ABBA_1	74:79	Mutation rewiring degron network	0.0833
p.N65S	ACH-001669	Leukemia	CCLE	LIPHTD	LIG_APCC_ABBA_1	74:79	Mutation rewiring degron network	0.0833
p.N65S	ACH-002238	Leukemia	CCLE	LIPHTD	LIG_APCC_ABBA_1	74:79	Mutation rewiring degron network	0.0833
p.N65S	GR-ST	haematopoietic and lymphoid tissue	COSMIC	LIPHTD	LIG_APCC_ABBA_1	74:79	Mutation rewiring degron network	0.0833
p.E280K	TCGA-BA-6868	HNSC	TCGA	SRQNLDTIV	DEG_APCC_DBOX_1	265:273	Mutation rewiring degron network	0.1389
p.E280K	DO14184	HNSC	ICGC	SRQNLDTIV	DEG_APCC_DBOX_1	265:273	Mutation rewiring degron network	0.1389
p.P255S	TCGA-D3-A5GO	SKCM	TCGA	SRQNLDTIV	DEG_APCC_DBOX_1	265:273	Mutation rewiring degron network	0.0556
p.P255S	DO47419	SKCM	ICGC	SRQNLDTIV	DEG_APCC_DBOX_1	265:273	Mutation rewiring degron network	0.0556
p.G281V	TCGA-F4-6807	COAD	TCGA	SRQNLDTIV	DEG_APCC_DBOX_1	265:273	Mutation rewiring degron network	0.1111
p.G281V	DO9716	COAD	ICGC	SRQNLDTIV	DEG_APCC_DBOX_1	265:273	Mutation rewiring degron network	0.1111
p.G281D	TCGA-HU-A4H8	STAD	TCGA	SRQNLDTIV	DEG_APCC_DBOX_1	265:273	Mutation rewiring degron network	0.1111
p.G281D	DO47869	STAD	ICGC	SRQNLDTIV	DEG_APCC_DBOX_1	265:273	Mutation rewiring degron network	0.1111
p.T271I	TCGA-WE-AAA0	SKCM	TCGA	SRQNLDTIV	DEG_APCC_DBOX_1	265:273	Mutation altering degron motif	0.5966
p.T271I	DO51294	SKCM	ICGC	SRQNLDTIV	DEG_APCC_DBOX_1	265:273	Mutation altering degron motif	0.5966
p.T282N	DO228952	LICA	ICGC	SRQNLDTIV	DEG_APCC_DBOX_1	265:273	Mutation blocking phosphorylation signal	0.5278
p.H77N	DO229025	LICA	ICGC	LIPHTD	LIG_APCC_ABBA_1	74:79	Mutation altering degron motif	0.7423
p.K85R	DO218697	ORCA	ICGC	LIPHTD	LIG_APCC_ABBA_1	74:79	Mutation substituting flanking lysine	0.2778
p.S261F	DO232056	ORCA	ICGC	SRQNLDTIV	DEG_APCC_DBOX_1	265:273	Mutation rewiring degron network	0.2222
p.I88T	ACH-000088	Non-Cancerous	CCLE	LIPHTD	LIG_APCC_ABBA_1	74:79	Mutation rewiring degron network	0.0833
p.I75L	ACH-000660	Lymphoma	CCLE	LIPHTD	LIG_APCC_ABBA_1	74:79	Mutation altering degron motif	0.6063
p.I75L	SU-DHL-5	haematopoietic and lymphoid tissue	COSMIC	LIPHTD	LIG_APCC_ABBA_1	74:79	Mutation altering degron motif	0.6063

Kaplan plot for TFAP4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TFAP4

UniProt ID: Q01664

Entrez ID: 7023

Protein name: Transcription factor AP-4 (Activating enhancer-binding protein 4) (Class C basic helix-loop-helix protein 41) (bHLHc41)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TFAP4 in