DegronMD

Uniprot ID: Q01664

Source protein: Transcription factor AP-4

Source gene: TFAP4

Class: DEG_APCC_DBOX_1

Location: 265:273

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6031

ASA_SCORE: 61.4111

COIL: 0.3738

CONS_SCORE: 0.575

DSS_SCORE: 0.3736

HELIX: 0.5948

FCONS_SCORE: 1.2007

RIG_SCORE: 0.7646

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E280K	TCGA-BA-6868	HNSC	TCGA	SRQNLDTIV	DEG_APCC_DBOX_1	0.1389
p.E280K	DO14184	HNSC	ICGC	SRQNLDTIV	DEG_APCC_DBOX_1	0.1389
p.P255S	TCGA-D3-A5GO	SKCM	TCGA	SRQNLDTIV	DEG_APCC_DBOX_1	0.0556
p.P255S	DO47419	SKCM	ICGC	SRQNLDTIV	DEG_APCC_DBOX_1	0.0556
p.G281V	TCGA-F4-6807	COAD	TCGA	SRQNLDTIV	DEG_APCC_DBOX_1	0.1111
p.G281V	DO9716	COAD	ICGC	SRQNLDTIV	DEG_APCC_DBOX_1	0.1111
p.G281D	TCGA-HU-A4H8	STAD	TCGA	SRQNLDTIV	DEG_APCC_DBOX_1	0.1111
p.G281D	DO47869	STAD	ICGC	SRQNLDTIV	DEG_APCC_DBOX_1	0.1111
p.T271I	TCGA-WE-AAA0	SKCM	TCGA	SRQNLDTIV	DEG_APCC_DBOX_1	0.5966
p.T271I	DO51294	SKCM	ICGC	SRQNLDTIV	DEG_APCC_DBOX_1	0.5966
p.T282N	DO228952	LICA	ICGC	SRQNLDTIV	DEG_APCC_DBOX_1	0.5278
p.S261F	DO232056	ORCA	ICGC	SRQNLDTIV	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01664	Transcription factor AP-4	DEG_APCC_DBOX_1	265:273	SRQNLDTIV	APC,CDC20,FZR1	0.6031	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons