DegronMD

Uniprot ID: P24864

Source protein: G1/S-specific cyclin-E1

Source gene: CCNE1

Class: DEG_SCF_FBW7_2

Location: 74:81

E3 ligase: FBXW7

DEGRON score: 0.9971

ASA_SCORE: 98.7125

COIL: 0.9115

CONS_SCORE: 0.3928

DSS_SCORE: 0.4787

HELIX: 0.0544

FCONS_SCORE: 1.0371

RIG_SCORE: 0.7043

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S90L	TCGA-A5-A0G2	UCEC	TCGA	LIPTPDKE	DEG_SCF_FBW7_2	0.5278
p.S90L	DO41235	UCEC	ICGC	LIPTPDKE	DEG_SCF_FBW7_2	0.5278
p.N64I	TCGA-B5-A11H	UCEC	TCGA	LIPTPDKE	DEG_SCF_FBW7_2	0.0556
p.N64I	DO42825	UCEC	ICGC	LIPTPDKE	DEG_SCF_FBW7_2	0.0556
p.D83N	TCGA-EA-A3HS	CESC	TCGA	LIPTPDKE	DEG_SCF_FBW7_2	0.2778
p.D83N	DO6260	CESC	ICGC	LIPTPDKE	DEG_SCF_FBW7_2	0.2778
p.D83N	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	LIPTPDKE	DEG_SCF_FBW7_2	0.2778
p.D83N	SIDM01578	Bladder Carcinoma	GDSC	LIPTPDKE	DEG_SCF_FBW7_2	0.2778
p.D83N	ACH-000862	Bladder Cancer	CCLE	LIPTPDKE	DEG_SCF_FBW7_2	0.2778
p.D83N	ACH-000900	Lung Cancer	CCLE	LIPTPDKE	DEG_SCF_FBW7_2	0.2778
p.D83N	NCI-H23	lung	COSMIC	LIPTPDKE	DEG_SCF_FBW7_2	0.2778
p.D83G	TCGA-HD-A6HZ	HNSC	TCGA	LIPTPDKE	DEG_SCF_FBW7_2	0.2778
p.D83G	DO49998	HNSC	ICGC	LIPTPDKE	DEG_SCF_FBW7_2	0.2778
p.C68F	SIDM00697	Small Cell Lung Carcinoma	GDSC	LIPTPDKE	DEG_SCF_FBW7_2	0.1667
p.C68F	ACH-000830	Lung Cancer	CCLE	LIPTPDKE	DEG_SCF_FBW7_2	0.1667
p.C68F	NCI-H1436	lung	COSMIC	LIPTPDKE	DEG_SCF_FBW7_2	0.1667
p.T91M	SIDM00933	Breast Carcinoma	GDSC	LIPTPDKE	DEG_SCF_FBW7_2	0.0556
p.T91M	ACH-000856	Breast Cancer	CCLE	LIPTPDKE	DEG_SCF_FBW7_2	0.0556
p.T91M	CAL-51	breast	COSMIC	LIPTPDKE	DEG_SCF_FBW7_2	0.0556
p.A69S	ACH-000901	Lung Cancer	CCLE	LIPTPDKE	DEG_SCF_FBW7_2	0.1944
p.R80L	M059J	central_nervous_system	COSMIC	LIPTPDKE	DEG_SCF_FBW7_2	0.8428
p.D68N	NCI-H23	lung	COSMIC	LIPTPDKE	DEG_SCF_FBW7_2	0.1667
p.T76M	CAL-51	breast	COSMIC	LIPTPDKE	DEG_SCF_FBW7_2	0.7423
p.S85C	NCI-H187	lung	COSMIC	LIPTPDKE	DEG_SCF_FBW7_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P24864	G1/S-specific cyclin-E1	DEG_SCF_FBW7_2	74:81	LIPTPDKE	FBXW7	0.9971	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons