DegronMD - P24864(CCNE1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R385T	TCGA-64-5774	LUAD	TCGA	LLTPPQS	DEG_SCF_FBW7_1	393:399	Mutation rewiring degron network	0.1111
p.R385T	DO24770	LUAD	ICGC	LLTPPQS	DEG_SCF_FBW7_1	393:399	Mutation rewiring degron network	0.1111
p.R385S	TCGA-64-5774	LUAD	TCGA	LLTPPQS	DEG_SCF_FBW7_1	393:399	Mutation rewiring degron network	0.1111
p.R385S	DO24770	LUAD	ICGC	LLTPPQS	DEG_SCF_FBW7_1	393:399	Mutation rewiring degron network	0.1111
p.A386S	TCGA-86-6851	LUAD	TCGA	LLTPPQS	DEG_SCF_FBW7_1	393:399	Mutation rewiring degron network	0.1389
p.A386S	DO23798	LUAD	ICGC	LLTPPQS	DEG_SCF_FBW7_1	393:399	Mutation rewiring degron network	0.1389
p.S90L	TCGA-A5-A0G2	UCEC	TCGA	LIPTPDKE	DEG_SCF_FBW7_2	74:81	Mutation blocking phosphorylation signal	0.5278
p.S90L	DO41235	UCEC	ICGC	LIPTPDKE	DEG_SCF_FBW7_2	74:81	Mutation blocking phosphorylation signal	0.5278
p.P407L	TCGA-AA-3877	COAD	TCGA	LLTPPQS	DEG_SCF_FBW7_1	393:399	Mutation rewiring degron network	0.1111
p.P407L	DO7855	COAD	ICGC	LLTPPQS	DEG_SCF_FBW7_1	393:399	Mutation rewiring degron network	0.1111
p.S399I	TCGA-AP-A051	UCEC	TCGA	LLTPPQS	DEG_SCF_FBW7_1	393:399	Mutation altering degron motif	0.8453
p.S399I	DO228986	LICA	ICGC	LLTPPQS	DEG_SCF_FBW7_1	393:399	Mutation altering degron motif	0.8453
p.S399I	DO42673	UCEC	ICGC	LLTPPQS	DEG_SCF_FBW7_1	393:399	Mutation altering degron motif	0.8453
p.N64I	TCGA-B5-A11H	UCEC	TCGA	LIPTPDKE	DEG_SCF_FBW7_2	74:81	Mutation rewiring degron network	0.0556
p.N64I	DO42825	UCEC	ICGC	LIPTPDKE	DEG_SCF_FBW7_2	74:81	Mutation rewiring degron network	0.0556
p.P396L	TCGA-DF-A2KN	UCEC	TCGA	LLTPPQS	DEG_SCF_FBW7_1	393:399	Mutation altering degron motif	0.7582
p.P396L	DO233628	GACA	ICGC	LLTPPQS	DEG_SCF_FBW7_1	393:399	Mutation altering degron motif	0.7582
p.P396L	DO223282	UCEC	ICGC	LLTPPQS	DEG_SCF_FBW7_1	393:399	Mutation altering degron motif	0.7582
p.D83N	TCGA-EA-A3HS	CESC	TCGA	LIPTPDKE	DEG_SCF_FBW7_2	74:81	Mutation rewiring degron network	0.2778
p.D83N	DO6260	CESC	ICGC	LIPTPDKE	DEG_SCF_FBW7_2	74:81	Mutation rewiring degron network	0.2778
p.D83N	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	LIPTPDKE	DEG_SCF_FBW7_2	74:81	Mutation rewiring degron network	0.2778
p.D83N	SIDM01578	Bladder Carcinoma	GDSC	LIPTPDKE	DEG_SCF_FBW7_2	74:81	Mutation rewiring degron network	0.2778
p.D83N	ACH-000862	Bladder Cancer	CCLE	LIPTPDKE	DEG_SCF_FBW7_2	74:81	Mutation rewiring degron network	0.2778
p.D83N	ACH-000900	Lung Cancer	CCLE	LIPTPDKE	DEG_SCF_FBW7_2	74:81	Mutation rewiring degron network	0.2778
p.D83N	NCI-H23	lung	COSMIC	LIPTPDKE	DEG_SCF_FBW7_2	74:81	Mutation rewiring degron network	0.2778
p.D83G	TCGA-HD-A6HZ	HNSC	TCGA	LIPTPDKE	DEG_SCF_FBW7_2	74:81	Mutation rewiring degron network	0.2778
p.D83G	DO49998	HNSC	ICGC	LIPTPDKE	DEG_SCF_FBW7_2	74:81	Mutation rewiring degron network	0.2778
p.T395I	TCGA-QB-AA9O	SKCM	TCGA	LLTPPQS	DEG_SCF_FBW7_1	393:399	Mutation altering degron motif	0.8189
p.T395I	DO233146	GACA	ICGC	LLTPPQS	DEG_SCF_FBW7_1	393:399	Mutation altering degron motif	0.8189
p.T395I	DO51267	SKCM	ICGC	LLTPPQS	DEG_SCF_FBW7_1	393:399	Mutation altering degron motif	0.8189
p.G406W	DO228978	LICA	ICGC	LLTPPQS	DEG_SCF_FBW7_1	393:399	Mutation rewiring degron network	0.1389
p.S399R	DO232832	NACA	ICGC	LLTPPQS	DEG_SCF_FBW7_1	393:399	Mutation altering degron motif	0.8538
p.S399R	SIDM00739	Non-Small Cell Lung Carcinoma	GDSC	LLTPPQS	DEG_SCF_FBW7_1	393:399	Mutation altering degron motif	0.8538
p.S399R	ACH-000675	Lung Cancer	CCLE	LLTPPQS	DEG_SCF_FBW7_1	393:399	Mutation altering degron motif	0.8538
p.S399R	NCI-H1734	lung	COSMIC	LLTPPQS	DEG_SCF_FBW7_1	393:399	Mutation altering degron motif	0.8538
p.G400D	DO229232	THCA	ICGC	LLTPPQS	DEG_SCF_FBW7_1	393:399	Mutation rewiring degron network	0.3056
p.L394I	DO41056	UCEC	ICGC	LLTPPQS	DEG_SCF_FBW7_1	393:399	Mutation altering degron motif	0.6063
p.C68F	SIDM00697	Small Cell Lung Carcinoma	GDSC	LIPTPDKE	DEG_SCF_FBW7_2	74:81	Mutation rewiring degron network	0.1667
p.C68F	ACH-000830	Lung Cancer	CCLE	LIPTPDKE	DEG_SCF_FBW7_2	74:81	Mutation rewiring degron network	0.1667
p.C68F	NCI-H1436	lung	COSMIC	LIPTPDKE	DEG_SCF_FBW7_2	74:81	Mutation rewiring degron network	0.1667
p.T91M	SIDM00933	Breast Carcinoma	GDSC	LIPTPDKE	DEG_SCF_FBW7_2	74:81	Mutation rewiring degron network	0.0556
p.T91M	ACH-000856	Breast Cancer	CCLE	LIPTPDKE	DEG_SCF_FBW7_2	74:81	Mutation rewiring degron network	0.0556
p.T91M	CAL-51	breast	COSMIC	LIPTPDKE	DEG_SCF_FBW7_2	74:81	Mutation rewiring degron network	0.0556
p.N384K	SIDM00699	Small Cell Lung Carcinoma	GDSC	LLTPPQS	DEG_SCF_FBW7_1	393:399	Mutation rewiring degron network	0.0833
p.N384K	ACH-001138	Lung Cancer	CCLE	LLTPPQS	DEG_SCF_FBW7_1	393:399	Mutation rewiring degron network	0.0833
p.N384K	NCI-H2141	lung	COSMIC	LLTPPQS	DEG_SCF_FBW7_1	393:399	Mutation rewiring degron network	0.0833
p.M409V	SIDM01490	Small Cell Lung Carcinoma	GDSC	LLTPPQS	DEG_SCF_FBW7_1	393:399	Mutation rewiring degron network	0.0556
p.M409V	ACH-000382	Lung Cancer	CCLE	LLTPPQS	DEG_SCF_FBW7_1	393:399	Mutation rewiring degron network	0.0556
p.A69S	ACH-000901	Lung Cancer	CCLE	LIPTPDKE	DEG_SCF_FBW7_2	74:81	Mutation rewiring degron network	0.1944
p.G406E	ACH-002669	Colon/Colorectal Cancer	CCLE	LLTPPQS	DEG_SCF_FBW7_1	393:399	Mutation rewiring degron network	0.1389
p.R80L	M059J	central nervous system	COSMIC	LIPTPDKE	DEG_SCF_FBW7_2	74:81	Mutation altering degron motif	0.8428
p.D68N	NCI-H23	lung	COSMIC	LIPTPDKE	DEG_SCF_FBW7_2	74:81	Mutation rewiring degron network	0.1667
p.T76M	CAL-51	breast	COSMIC	LIPTPDKE	DEG_SCF_FBW7_2	74:81	Mutation altering degron motif	0.7423
p.S85C	NCI-H187	lung	COSMIC	LIPTPDKE	DEG_SCF_FBW7_2	74:81	Mutation rewiring degron network	0.2222
p.S384R	NCI-H1734	lung	COSMIC	LLTPPQS	DEG_SCF_FBW7_1	393:399	Mutation rewiring degron network	0.0833

Kaplan plot for CCNE1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCNE1

UniProt ID: P24864

Entrez ID: 898

Protein name: G1/S-specific cyclin-E1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCNE1 in