DegronMD

Uniprot ID: P24864

Source protein: G1/S-specific cyclin-E1

Source gene: CCNE1

Class: DEG_SCF_FBW7_1

Location: 393:399

E3 ligase: FBXW7

DEGRON score: 0.9994

ASA_SCORE: 76.2

COIL: 0.8276

CONS_SCORE: 0.457

DSS_SCORE: 0.7889

HELIX: 0.0146

FCONS_SCORE: 1.2512

RIG_SCORE: 0.5784

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R385T	TCGA-64-5774	LUAD	TCGA	LLTPPQS	DEG_SCF_FBW7_1	0.1111
p.R385T	DO24770	LUAD	ICGC	LLTPPQS	DEG_SCF_FBW7_1	0.1111
p.R385S	TCGA-64-5774	LUAD	TCGA	LLTPPQS	DEG_SCF_FBW7_1	0.1111
p.R385S	DO24770	LUAD	ICGC	LLTPPQS	DEG_SCF_FBW7_1	0.1111
p.A386S	TCGA-86-6851	LUAD	TCGA	LLTPPQS	DEG_SCF_FBW7_1	0.1389
p.A386S	DO23798	LUAD	ICGC	LLTPPQS	DEG_SCF_FBW7_1	0.1389
p.P407L	TCGA-AA-3877	COAD	TCGA	LLTPPQS	DEG_SCF_FBW7_1	0.1111
p.P407L	DO7855	COAD	ICGC	LLTPPQS	DEG_SCF_FBW7_1	0.1111
p.S399I	TCGA-AP-A051	UCEC	TCGA	LLTPPQS	DEG_SCF_FBW7_1	0.8453
p.S399I	DO228986	LICA	ICGC	LLTPPQS	DEG_SCF_FBW7_1	0.8453
p.S399I	DO42673	UCEC	ICGC	LLTPPQS	DEG_SCF_FBW7_1	0.8453
p.P396L	TCGA-DF-A2KN	UCEC	TCGA	LLTPPQS	DEG_SCF_FBW7_1	0.7582
p.P396L	DO233628	GACA	ICGC	LLTPPQS	DEG_SCF_FBW7_1	0.7582
p.P396L	DO223282	UCEC	ICGC	LLTPPQS	DEG_SCF_FBW7_1	0.7582
p.T395I	TCGA-QB-AA9O	SKCM	TCGA	LLTPPQS	DEG_SCF_FBW7_1	0.8189
p.T395I	DO233146	GACA	ICGC	LLTPPQS	DEG_SCF_FBW7_1	0.8189
p.T395I	DO51267	SKCM	ICGC	LLTPPQS	DEG_SCF_FBW7_1	0.8189
p.G406W	DO228978	LICA	ICGC	LLTPPQS	DEG_SCF_FBW7_1	0.1389
p.S399R	DO232832	NACA	ICGC	LLTPPQS	DEG_SCF_FBW7_1	0.8538
p.S399R	SIDM00739	Non-Small Cell Lung Carcinoma	GDSC	LLTPPQS	DEG_SCF_FBW7_1	0.8538
p.S399R	ACH-000675	Lung Cancer	CCLE	LLTPPQS	DEG_SCF_FBW7_1	0.8538
p.S399R	NCI-H1734	lung	COSMIC	LLTPPQS	DEG_SCF_FBW7_1	0.8538
p.G400D	DO229232	THCA	ICGC	LLTPPQS	DEG_SCF_FBW7_1	0.3056
p.L394I	DO41056	UCEC	ICGC	LLTPPQS	DEG_SCF_FBW7_1	0.6063
p.N384K	SIDM00699	Small Cell Lung Carcinoma	GDSC	LLTPPQS	DEG_SCF_FBW7_1	0.0833
p.N384K	ACH-001138	Lung Cancer	CCLE	LLTPPQS	DEG_SCF_FBW7_1	0.0833
p.N384K	NCI-H2141	lung	COSMIC	LLTPPQS	DEG_SCF_FBW7_1	0.0833
p.M409V	SIDM01490	Small Cell Lung Carcinoma	GDSC	LLTPPQS	DEG_SCF_FBW7_1	0.0556
p.M409V	ACH-000382	Lung Cancer	CCLE	LLTPPQS	DEG_SCF_FBW7_1	0.0556
p.G406E	ACH-002669	Colon/Colorectal Cancer	CCLE	LLTPPQS	DEG_SCF_FBW7_1	0.1389
p.S384R	NCI-H1734	lung	COSMIC	LLTPPQS	DEG_SCF_FBW7_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LLTPPQS

Degron related mutations and impact score

Drug responses associated with CCNE1 mutations

All proteins holding degron of LLTPPQS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P24864	G1/S-specific cyclin-E1	DEG_SCF_FBW7_1	393:399	LLTPPQS	FBXW7	0.9994	More...